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Diffusion model for ultrasound-modulated light

Hollmann, Joseph L. and Horstmeyer, Roarke and Yang, Changhuei and DiMarzio, Charles A. (2014) Diffusion model for ultrasound-modulated light. Journal of Biomedical Optics, 19 (3). Art. No. 035005. ISSN 1083-3668. https://resolver.caltech.edu/CaltechAUTHORS:20140731-094446383

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Abstract

Researchers use ultrasound (US) to modulate diffusive light in a highly scattering medium like tissue. This paper analyzes the US–optical interaction in the scattering medium and derives an expression for the US-modulated optical radiance. The diffusion approximation to the radiative transport equation is employed to develop a Green’s function for US-modulated light. The predicted modulated fluence and flux are verified using finite-difference time-domain simulations. The Green’s function is then utilized to illustrate the modulated reflectance as the US–optical interaction increases in depth. The intent of this paper is to focus on high US frequencies necessary for high-resolution imaging because they are of interest for applications such as phase conjugation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.JBO.19.3.035005 DOIArticle
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1850278PublisherArticle
ORCID:
AuthorORCID
Horstmeyer, Roarke0000-0002-2480-9141
Additional Information:© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE). Paper 130709RR received Sep. 29, 2013; revised manuscript received Jan. 29, 2014; accepted for publication Jan. 30, 2014; published online Mar. 17, 2014. J. Hollmann acknowledges support from the National Science Foundation Graduate Fellowship awarded through the East Asia and Pacific Summer Institutes for U.S. Graduate Students. R. Horstmeyer acknowledges support from the National Defense Science and Engineering Graduate fellowship awarded through the Air Force Office of Scientific Research.
Funders:
Funding AgencyGrant Number
NSF Graduate Research FellowshipUNSPECIFIED
East Asia and Pacific Summer Institutes for U.S. Graduate StudentsUNSPECIFIED
National Defense Science and Engineering Graduate (NDSEG) FellowshipUNSPECIFIED
Air Force Office of Scientific Research (AFOSR)UNSPECIFIED
Subject Keywords:ultrasound modulation of light; diffusion; finite-difference time-domain
Issue or Number:3
Record Number:CaltechAUTHORS:20140731-094446383
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140731-094446383
Official Citation:Hollmann JL, Horstmeyer R, Yang C, DiMarzio CA; Diffusion model for ultrasound-modulated light. J. Biomed. Opt. 0001;19(3):035005. doi:10.1117/1.JBO.19.3.035005
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:47700
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:31 Jul 2014 18:50
Last Modified:03 Oct 2019 06:56

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