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The Induction of Mutations by Antibodies

Emerson, Sterling (1944) The Induction of Mutations by Antibodies. Proceedings of the National Academy of Sciences of the United States of America, 30 (8). pp. 179-183. ISSN 0027-8424.

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In most biological syntheses each step is controlled by a different gene. This conclusion was suggested by such combined genetic and biochemical studies as those on the anthocyanin pigments from which it appeared that a particular gene regulates the oxidation (or methylation, or the nature of the glucosides) at particular carbon atoms of the anthocyanin molecules. Studies of the eye pigments of Drosophila and the hair pigments of guinea pigs each indicate that the different steps in a particular synthesis are controlled by different genes. Almost overwhelming support for the conclusion is coming from studies of "biochemical" mutations in Neurospora.

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Additional Information:Copyright © 1944 National Academy of Sciences. Communicated July 5, 1944. Work supported in part by a grant from the Rockefeller Foundation. The author wishes to express his indebtedness to Professor G. W. Beadle for the stocks of Neurospora used and for making available unpublished methods developed by him and his collaborators. I am also indebted to my colleagues in this Institution and at Stanford University for many helpful discussions.
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Rockefeller FoundationUNSPECIFIED
Issue or Number:8
Record Number:CaltechAUTHORS:20140731-162716057
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:47751
Deposited By: George Porter
Deposited On:01 Aug 2014 14:27
Last Modified:03 Oct 2019 06:56

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