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Microfluidic-integrated laser-controlled microactuators with on-chip microscopy imaging functionality

Jung, Jae Hee and Han, Chao and Lee, Seung Ah and Kim, Jinho and Yang, Changhuei (2014) Microfluidic-integrated laser-controlled microactuators with on-chip microscopy imaging functionality. Lab on a Chip, 14 (19). pp. 3781-3789. ISSN 1473-0197. PMCID PMC4153594.

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The fabrication of a novel microfluidic system, integrated with a set of laser-controlled microactuators on an ePetri on-chip microscopy platform, is presented in this paper. In the fully integrated microfluidic system, a set of novel thermally actuated paraffin-based microactuators, precisely controlled by programmed laser optics, was developed to regulate flow and to provide pumping of liquid solutions without external connections. The microfluidic chip was fabricated on a complementary metal–oxide–semiconductor (CMOS)-imaging sensor chip on an ePetri platform; this configuration provided real-time, wide field-of-view, high-resolution imaging using a sub-pixel sweeping microscopy technique. The system of microactuators, which consisted of microvalves and a micropump, operated well in the microfluidic channel with a focused near-infrared laser beam providing the actuation control. As a demonstration, we used our prototype to assess cell–drug interactions and to monitor cell growth directly within an incubator in real time. The powerful combination of laser-actuated microfluidics and chip-scale microscopy techniques represents a significant step forward in terms of a simple, robust, high-throughput, and highly compact analysis system for biomedical and bioscience applications.

Item Type:Article
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URLURL TypeDescription DOIArticle CentralArticle
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2014 Royal Society of Chemistry. Received 08 July 2014; accepted 24 July 2014; first published online 25 July 2014. This research was supported by the National Institutes of Health under grant no. 1R01AI096226-01 and in part by the KIST Institutional Program (2E24652).
Funding AgencyGrant Number
Korea Institute of Science and Technology (KIST)UNSPECIFIED
Issue or Number:19
PubMed Central ID:PMC4153594
Record Number:CaltechAUTHORS:20140811-084244344
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Official Citation:Jung, J. H., Han, C., Lee, S. A., Kim, J., & Yang, C. (2014). Microfluidic-integrated laser-controlled microactuators with on-chip microscopy imaging functionality. [10.1039/C4LC00790E]. Lab on a Chip. doi: 10.1039/c4lc00790e
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:48281
Deposited By: Jason Perez
Deposited On:11 Aug 2014 19:17
Last Modified:09 Mar 2020 13:19

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