A Caltech Library Service

Dynamic biomacromolecular patterning of photoresponsive hydrogels

Tirrell, David A. and DeForest, Cole A. (2014) Dynamic biomacromolecular patterning of photoresponsive hydrogels. In: 248th American Chemical Society National Meeting & Exposition, August 10-14, 2014, San Francisco, CA.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Polymer-based hydrogels have emerged as a unique class of biomaterials that enable stem cells to be cultured in three-dimensions within near-physiol., synthetic microenvironments. Recent strategies have been developed that permit bioepitopes (e.g., peptides, full-length proteins) to be introduced at any point in time and space to affect cell function spatiotemporally within user-defined subvolumes of the bulk material. While these techniques have been successfully utilized to direct a variety of basic cellular functions, advanced platforms that permit biol. cues to be both introduced and subsequently removed would be beneficial in recapitulating the dynamic abundance of signaling biomols. in the native, temporally-variable niche and in modulating complex cellular behavior. In this work, we demonstrate that the combination of two bioorthogonal light-based chemistries provides for the reversible immobilization of protein cues spatially within a hydrogel. The highlighted approach enables precise control over 4D biochem. functionalization of a synthetic polymer network in response to user-defined photonic stimuli. Results further highlight the versatility of such dynamic biomacromol. signal presentation in better understanding basic cell physiol.

Item Type:Conference or Workshop Item (Paper)
Related URLs:
URLURL TypeDescription Website
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 2014 American Chemical Society.
Record Number:CaltechAUTHORS:20140811-130624245
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:48310
Deposited By: Tony Diaz
Deposited On:11 Aug 2014 20:54
Last Modified:03 Oct 2019 07:02

Repository Staff Only: item control page