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Multiple Products of the Drosophila Shaker Gene May Contribute to Potassium Channel Diversity

Kamb, Alexander and Tseng-Crank, Julie and Tanouye, Mark A. (1988) Multiple Products of the Drosophila Shaker Gene May Contribute to Potassium Channel Diversity. Neuron, 1 (5). pp. 421-430. ISSN 0896-6273. http://resolver.caltech.edu/CaltechAUTHORS:20140812-131531957

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Abstract

K+ channels are known through electrophysiology and pharmacology to be an exceptionally diverse group of channels. Molecular studies of the Shaker (Sh) locus in Drosophila have provided the first glimpse of K+ channel structure. The sequences of several Sh cDNA clones have been reported; none are identical. We have isolated and examined 18 additional Sh cDNAs in an attempt to understand the origin, extent, and significance of the variability. The diversity is extensive: we have already identified cDNAs representing at least nine distinct types, and Sh could potentially encode 24 or more products. This diversity, however, fits a simple pattern in which variable 3′ and 5′ ends are spliced onto a central constant region to yield different cDNA types. These different Sh cDNAs encode proteins with distinct structural features.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0896-6273(88)90192-4DOIArticle
http://www.sciencedirect.com/science/article/pii/0896627388901924PublisherArticle
Additional Information:© 1988 Cell Press. Received February 29, 1988; revised May 27, 1988. We thank M. Gautam, L. Iverson, M. Mathew, M. Ramaswami, and B. Rudy for helpful discussions and R. McMahon for technical assistance. This research was supported by the Pfeiffer Research Foundation and by USPHS grant NS21327-01 to M. A. T. J. T.-C. was supported by NIH training grant NS07251. M. A. T. is a McKnight Foundation Scholar and a Sloan Foundation Fellow.
Funders:
Funding AgencyGrant Number
Pfeiffer Research FoundationUNSPECIFIED
USPHSNS21327-01
NIHNS07251
Knight FoundationUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20140812-131531957
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140812-131531957
Official Citation:Kamb, A., Tseng-Crank, J., & Tanouye, M. A. (1988). Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity. Neuron, 1(5), 421-430. doi: http://dx.doi.org/10.1016/0896-6273(88)90192-4
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ID Code:48408
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:12 Aug 2014 20:40
Last Modified:12 Aug 2014 20:40

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