A Caltech Library Service

Multiple Products of the Drosophila Shaker Gene May Contribute to Potassium Channel Diversity

Kamb, Alexander and Tseng-Crank, Julie and Tanouye, Mark A. (1988) Multiple Products of the Drosophila Shaker Gene May Contribute to Potassium Channel Diversity. Neuron, 1 (5). pp. 421-430. ISSN 0896-6273. doi:10.1016/0896-6273(88)90192-4.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


K+ channels are known through electrophysiology and pharmacology to be an exceptionally diverse group of channels. Molecular studies of the Shaker (Sh) locus in Drosophila have provided the first glimpse of K+ channel structure. The sequences of several Sh cDNA clones have been reported; none are identical. We have isolated and examined 18 additional Sh cDNAs in an attempt to understand the origin, extent, and significance of the variability. The diversity is extensive: we have already identified cDNAs representing at least nine distinct types, and Sh could potentially encode 24 or more products. This diversity, however, fits a simple pattern in which variable 3′ and 5′ ends are spliced onto a central constant region to yield different cDNA types. These different Sh cDNAs encode proteins with distinct structural features.

Item Type:Article
Related URLs:
URLURL TypeDescription
Additional Information:© 1988 Cell Press. Received February 29, 1988; revised May 27, 1988. We thank M. Gautam, L. Iverson, M. Mathew, M. Ramaswami, and B. Rudy for helpful discussions and R. McMahon for technical assistance. This research was supported by the Pfeiffer Research Foundation and by USPHS grant NS21327-01 to M. A. T. J. T.-C. was supported by NIH training grant NS07251. M. A. T. is a McKnight Foundation Scholar and a Sloan Foundation Fellow.
Funding AgencyGrant Number
Pfeiffer Research FoundationUNSPECIFIED
Knight FoundationUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20140812-131531957
Persistent URL:
Official Citation:Kamb, A., Tseng-Crank, J., & Tanouye, M. A. (1988). Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity. Neuron, 1(5), 421-430. doi:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:48408
Deposited By: Jason Perez
Deposited On:12 Aug 2014 20:40
Last Modified:10 Nov 2021 18:31

Repository Staff Only: item control page