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Antisera that Block Cell Division in Developing Eggs of Sea Urchins

Tyler, Albert and Brookbank, John W. (1956) Antisera that Block Cell Division in Developing Eggs of Sea Urchins. Proceedings of the National Academy of Sciences of the United States of America, 42 (5). pp. 304-308. ISSN 0027-8424.

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As part of a program of investigation [1, 2, 3] of problems of fertilization and early development, the senior author has prepared antisera against various materials obtained from eggs, sperm, embryos, and adults of several species of sea urchins. In the course of the tests on developing eggs, it was observed that certain of the antisera blocked cleavage very effectively. The various antisera produced against fertilizin were found to be particularly effective cleavage-blocking agents. This seemed of special interest, since fertilizin is known [1-5] to be the sperm-receptor substance that constitutes the surface coat of the egg and is now chemically rather well defined. The cleavage-blocking action was therefore further investigated. In the present paper the results of a survey of the action of various kinds of antisera are presented.

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Additional Information:Copyright © 1956 by the National Academy of Sciences Communicated by A. H. Sturtevant, March 9, 1956 This investigation was supported by a research grant (C-2302) from the National Cancer Institute of the National Institutes of Health, Public Health Service. We are indebted to Miss Mary Jones for her excellent assistance in this work. An abstract has been published in Science, 122, 881, 1955.
Issue or Number:5
Record Number:CaltechAUTHORS:TYLpnas56a
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4849
Deposited By: Archive Administrator
Deposited On:11 Sep 2006
Last Modified:02 Oct 2019 23:16

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