Furst, Ariel L. and Hill, Michael G. and Barton, Jacqueline K. (2014) Two electrode platforms for DNA sensing based on DNA charge transport. In: 248th American Chemical Society National Meeting & Exposition, August 10-14, 2014, San Francisco, CA. https://resolver.caltech.edu/CaltechAUTHORS:20140814-094753667
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Abstract
Recently, we have developed a new DNA array platform that is formed electrochem. and addressed using a secondary electrode. Electrochem. activation of a copper catalyst, patterned with one electrode, enables precise placement of different DNA sequences onto a second electrode surface. The two-electrode patterning and detection platform allows for both high spatial resoln. of the patterned DNA array and optimization of detection through DNA-mediated charge transport with electrocatalysis. These platforms have been used for the successful detection of single base mismatches, specific hybridization events, and sequence-specific binding of transcription factors. We describe the application of this two-electrode platform in the development of new cancer diagnostics.
| Item Type: | Conference or Workshop Item (Paper) | ||||||
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| Additional Information: | © 2014 American Chemical Society. | ||||||
| Record Number: | CaltechAUTHORS:20140814-094753667 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20140814-094753667 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 48553 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 14 Aug 2014 20:58 | ||||||
| Last Modified: | 03 Oct 2019 07:05 |
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