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Two electrode platforms for DNA sensing based on DNA charge transport

Furst, Ariel L. and Hill, Michael G. and Barton, Jacqueline K. (2014) Two electrode platforms for DNA sensing based on DNA charge transport. In: 248th American Chemical Society National Meeting & Exposition, August 10-14, 2014, San Francisco, CA.

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Recently, we have developed a new DNA array platform that is formed electrochem. and addressed using a secondary electrode. Electrochem. activation of a copper catalyst, patterned with one electrode, enables precise placement of different DNA sequences onto a second electrode surface. The two-electrode patterning and detection platform allows for both high spatial resoln. of the patterned DNA array and optimization of detection through DNA-mediated charge transport with electrocatalysis. These platforms have been used for the successful detection of single base mismatches, specific hybridization events, and sequence-specific binding of transcription factors. We describe the application of this two-electrode platform in the development of new cancer diagnostics.

Item Type:Conference or Workshop Item (Paper)
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Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2014 American Chemical Society.
Record Number:CaltechAUTHORS:20140814-094753667
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:48553
Deposited By: Tony Diaz
Deposited On:14 Aug 2014 20:58
Last Modified:03 Oct 2019 07:05

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