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In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy

Sta Maria, Naomi S. and Barnes, Samuel R. and Jacobs, Russell E. (2014) In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy. Magnetic Resonance Insights, 7 . pp. 15-21. ISSN 1178-623X. PMCID PMC4122546.

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Natural killer (NK) cells are a crucial part of the innate immune system and play critical roles in host anti-viral, anti-microbial, and antitumor responses. The elucidation of NK cell biology and their therapeutic use are actively being pursued with 200 clinical trials currently underway. In this review, we outline the role of NK cells in cancer immunotherapies and summarize current noninvasive imaging technologies used to track NK cells in vivo to investigate mechanisms of action, develop new therapies, and evaluate efficacy of adoptive transfer.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Barnes, Samuel R.0000-0002-1065-8442
Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© The authors, publisher and licensee Libertas Academica Limited. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. Received: February 24, 2014. resubmitted: April 29, 2014. accepted for publication: April 29, 2014. This work was funded in part by NIBIB EB000993 and the Beckman Institute. The authors acknowledge the contributions of Sharon Lin for invaluable assistance with animal- and cell-based work. Drs. Andrew Raubitschek and David Colcher (City of Hope, Duarte CA) provided cogent comments as well as animals and cells for our NK cell studies. Author Contributions: Conceived and designed the experiments: NSSM, SRB, and REJ. Analyzed the data: NSSM and SRB. Wrote the first draft of the manuscript: NSSM. Contributed to the writing of the manuscript: NSSM, SRB, and REJ. Agree with manuscript results and conclusions: NSSM, SRB, and REJ. Jointly developed the structure and arguments for the paper: NSSM, SRB, and REJ. Made critical revisions and approved final version: NSSM, SRB, and REJ. All authors reviewed and approved of the final manuscript.
Funding AgencyGrant Number
National Institute of Biomedical Imaging and BioengineeringEB000993
Caltech Beckman InstituteUNSPECIFIED
Subject Keywords:natural killer cells; immunotherapy; cell tracking; MRI; optical imaging; PET imaging
PubMed Central ID:PMC4122546
Record Number:CaltechAUTHORS:20140820-113208560
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Official Citation:Sta Maria et al. In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy. Magnetic Resonance Insights 2014:7 15–21 doi:10.4137/MRI.S13145.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:48731
Deposited By: Jason Perez
Deposited On:20 Aug 2014 19:56
Last Modified:09 Mar 2020 13:18

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