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A smartphone-based chip-scale microscope using ambient illumination

Lee, Seung Ah and Yang, Changhuei (2014) A smartphone-based chip-scale microscope using ambient illumination. Lab on a Chip, 14 (16). pp. 3056-3063. ISSN 1473-0197. PMCID PMC4124038.

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Portable chip-scale microscopy devices can potentially address various imaging needs in mobile healthcare and environmental monitoring. Here, we demonstrate the adaptation of a smartphone's camera to function as a compact lensless microscope. Unlike other chip-scale microscopy schemes, this method uses ambient illumination as its light source and does not require the incorporation of a dedicated light source. The method is based on the shadow imaging technique where the sample is placed on the surface of the image sensor, which captures direct shadow images under illumination. To improve the image resolution beyond the pixel size, we perform pixel super-resolution reconstruction with multiple images at different angles of illumination, which are captured while the user is manually tilting the device around any ambient light source, such as the sun or a lamp. The lensless imaging scheme allows for sub-micron resolution imaging over an ultra-wide field-of-view (FOV). Image acquisition and reconstruction are performed on the device using a custom-built Android application, constructing a stand-alone imaging device for field applications. We discuss the construction of the device using a commercial smartphone and demonstrate the imaging capabilities of our system.

Item Type:Article
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URLURL TypeDescription CentralArticle
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2014 The Royal Society of Chemistry. Received 2nd May 2014, Accepted 27th May 2014, First published online 27 May 2014. The authors thank Dr. Jiangtao Huangfu for his help with the hardware and Mr. Mooseok Jang and Mr. Donghun Ryu for testing of the prototype devices. This work was funded by the NIH grant 1R01AI096226-01 and the Whittier Foundations agency award 9900040.
Funding AgencyGrant Number
Whittier Foundation9900040
Issue or Number:16
PubMed Central ID:PMC4124038
Record Number:CaltechAUTHORS:20140821-083207520
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:48757
Deposited By: Tony Diaz
Deposited On:22 Aug 2014 06:10
Last Modified:09 Mar 2020 13:19

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