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Microfabricated rubber microscope using soft solid immersion lenses

Gambin, Yann and Legrand, Olivier and Quake, Stephen R. (2006) Microfabricated rubber microscope using soft solid immersion lenses. Applied Physics Letters, 88 (17). Art. No. 174102. ISSN 0003-6951. https://resolver.caltech.edu/CaltechAUTHORS:GAMapl06

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Abstract

We show here a technique of soft lithography to microfabricate efficient solid immersion lenses (SIL) out of rubber elastomers. The light collection efficiency of a lens system is described by its numerical aperture (NA), and is critical for applications as epifluorescence microscopy [B. Herman, Fluorescence Microscopy (BIOS Scientific, Oxford/Springer, United Kingdom, 1998). While most simple lens systems have numerical apertures less than 1, the lenses described here have NA=1.25. Better performance can be engineered though the use of compound designs; we used this principle to make compound solid immersion lenses (NA=1.32). An important application of these lenses will be as integrated optics for microfluidic devices. We incorporated them into a handheld rubber microscope for microfluidic flow cytometry and imaged single E. Coli cells by fluorescence.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1063/1.2194477DOIUNSPECIFIED
Additional Information:©2006 American Institute of Physics. Received 5 November 2005; accepted 6 March 2006; published online 24 April 2006 The authors would like to thank Todd Thorsen and Markus Enzelberger for helpful discussions. This work was supported by the DARPA Chips program and the US National Science Foundation.
Subject Keywords:soft lithography; lenses; optical microscopes
Issue or Number:17
Record Number:CaltechAUTHORS:GAMapl06
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:GAMapl06
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4884
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:12 Sep 2006
Last Modified:02 Oct 2019 23:17

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