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Intrinsic frequency for a systems approach to haemodynamic waveform analysis with clinical applications

Pahlevan, Niema M. and Tavallali, Peyman and Rinderknecht, Derek and Petrasek, Danny and Matthews, Ray V. and Hou, Thomas Y. and Gharib, Morteza (2014) Intrinsic frequency for a systems approach to haemodynamic waveform analysis with clinical applications. Journal of the Royal Society Interface, 11 (98). Art. No. 20140617 . ISSN 1742-5689. PMCID PMC4233710.

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The reductionist approach has dominated the fields of biology and medicine for nearly a century. Here, we present a systems science approach to the analysis of physiological waveforms in the context of a specific case, cardiovascular physiology. Our goal in this study is to introduce a methodology that allows for novel insight into cardiovascular physiology and to show proof of concept for a new index for the evaluation of the cardiovascular system through pressure wave analysis. This methodology uses a modified version of sparse time–frequency representation (STFR) to extract two dominant frequencies we refer to as intrinsic frequencies (IFs; ω_1 and ω_2). The IFs are the dominant frequencies of the instantaneous frequency of the coupled heart + aorta system before the closure of the aortic valve and the decoupled aorta after valve closure. In this study, we extract the IFs from a series of aortic pressure waves obtained from both clinical data and a computational model. Our results demonstrate that at the heart rate at which the left ventricular pulsatile workload is minimized the two IFs are equal (ω_1 = ω_2). Extracted IFs from clinical data indicate that at young ages the total frequency variation (Δω = ω_1 − ω_2) is close to zero and that Δω increases with age or disease (e.g. heart failure and hypertension). While the focus of this paper is the cardiovascular system, this approach can easily be extended to other physiological systems or any biological signal.

Item Type:Article
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URLURL TypeDescription​rsif.2014.0617 DOIArticle Supplement CentralArticle
Gharib, Morteza0000-0002-2204-9302
Additional Information:© 2014 The Author(s) Published by the Royal Society. Received: 9 June 2014; accepted: 13 June 2014. The authors (N.M.P., D.C.R. and M.C.) acknowledge the support from Caltech innovative initiative grant (CTI).
Funding AgencyGrant Number
Caltech Innovation Initiative (CI2)UNSPECIFIED
Subject Keywords:pulse wave analysis; systems science; cardiovascular disease; ventricular/arterial coupling; instantaneous frequency; arterial pressure
Issue or Number:98
PubMed Central ID:PMC4233710
Record Number:CaltechAUTHORS:20140825-134136758
Persistent URL:
Official Citation:Pahlevan NM, Tavallali P, Rinderknecht DG, Petrasek D, Matthews RV, Hou TY, Gharib M. 2014 Intrinsic frequency for a systems approach to haemodynamic waveform analysis with clinical applications. J. R. Soc Interface 11: 20140617.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:48854
Deposited By: Jason Perez
Deposited On:25 Aug 2014 23:11
Last Modified:03 Oct 2019 07:08

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