A Caltech Library Service

Molecular Sieving in Periodic Free-Energy Landscapes Created by Patterned Nanofilter Arrays

Fu, Jianping and Yoo, Juhwan and Han, Jongyoon (2006) Molecular Sieving in Periodic Free-Energy Landscapes Created by Patterned Nanofilter Arrays. Physical Review Letters, 97 (1). Art. No. 018103. ISSN 0031-9007. doi:10.1103/PhysRevLett.97.018103.

PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


We present an experimental study of Ogston-like sieving process of rodlike DNA in patterned periodic nanofluidic filter arrays. The electrophoretic motion of DNA through the array is described as a biased Brownian motion overcoming periodically modulated free-energy landscape. A kinetic model, constructed based on the equilibrium partitioning theory and the Kramers theory, explains the field-dependent mobility well. We further show experimental evidence of the crossover from Ogston-like sieving to entropic trapping, depending on the ratio between nanofilter constriction size and DNA size.

Item Type:Article
Related URLs:
URLURL TypeDescription
Additional Information:© 2006 The American Physical Society (Received 22 December 2005; published 7 July 2006) We acknowledge support from NSF (No. CTS-0347348), NIH (No. EB005743), and Singapore-MIT Alliance (SMA-II, CE program). J.Y. was supported by the Caltech Summer Undergraduate Research Program. We thank P. Mao for helping take the SEM images.
Funding AgencyGrant Number
Singapore-MIT Alliance for Research and Technology (SMART)UNSPECIFIED
Caltech Summer Undergraduate Research Fellowship (SURF)UNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:FUJprl06
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4898
Deposited By: Archive Administrator
Deposited On:12 Sep 2006
Last Modified:08 Nov 2021 20:20

Repository Staff Only: item control page