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Molecular Sieving in Periodic Free-Energy Landscapes Created by Patterned Nanofilter Arrays

Fu, Jianping and Yoo, Juhwan and Han, Jongyoon (2006) Molecular Sieving in Periodic Free-Energy Landscapes Created by Patterned Nanofilter Arrays. Physical Review Letters, 97 (1). Art. No. 018103. ISSN 0031-9007. https://resolver.caltech.edu/CaltechAUTHORS:FUJprl06

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Abstract

We present an experimental study of Ogston-like sieving process of rodlike DNA in patterned periodic nanofluidic filter arrays. The electrophoretic motion of DNA through the array is described as a biased Brownian motion overcoming periodically modulated free-energy landscape. A kinetic model, constructed based on the equilibrium partitioning theory and the Kramers theory, explains the field-dependent mobility well. We further show experimental evidence of the crossover from Ogston-like sieving to entropic trapping, depending on the ratio between nanofilter constriction size and DNA size.


Item Type:Article
Additional Information:© 2006 The American Physical Society (Received 22 December 2005; published 7 July 2006) We acknowledge support from NSF (No. CTS-0347348), NIH (No. EB005743), and Singapore-MIT Alliance (SMA-II, CE program). J.Y. was supported by the Caltech Summer Undergraduate Research Program. We thank P. Mao for helping take the SEM images.
Funders:
Funding AgencyGrant Number
NSFCTS-0347348
NIHEB005743
Singapore-MIT Alliance for Research and Technology (SMART)UNSPECIFIED
Caltech Summer Undergraduate Research Fellowship (SURF)UNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:FUJprl06
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:FUJprl06
Alternative URL:http://dx.doi.org/10.1103/PhysRevLett.97.018103
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4898
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:12 Sep 2006
Last Modified:02 Oct 2019 23:17

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