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Bioinformatic Analysis of Nematode Migration-Associated Genes Identifies Novel Vertebrate Neural Crest Markers

Kwon, Seung-Hae and Park, Ok Kyu and Nie, Shuyi and Kwak, Jina and Hwang, Byung Joon and Bronner, Marianne E. and Kee, Yun (2014) Bioinformatic Analysis of Nematode Migration-Associated Genes Identifies Novel Vertebrate Neural Crest Markers. PLoS ONE, 9 (7). Art. No. e103024. ISSN 1932-6203. PMCID PMC4106859. doi:10.1371/journal.pone.0103024.

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Neural crest cells are highly motile, yet a limited number of genes governing neural crest migration have been identified by conventional studies. To test the hypothesis that cell migration genes are likely to be conserved over large evolutionary distances and from diverse tissues, we searched for vertebrate homologs of genes important for migration of various cell types in the invertebrate nematode and examined their expression during vertebrate neural crest cell migration. Our systematic analysis utilized a combination of comparative genomic scanning, functional pathway analysis and gene expression profiling to uncover previously unidentified genes expressed by premigratory, emigrating and/or migrating neural crest cells. The results demonstrate that similar gene sets are expressed in migratory cell types across distant animals and different germ layers. Bioinformatics analysis of these factors revealed relationships between these genes within signaling pathways that may be important during neural crest cell migration.

Item Type:Article
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URLURL TypeDescription CentralArticle
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2014 Kwon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received: January 18, 2014; Accepted: June 26, 2014; Published: July 22, 2014. Funding: This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) (2011-0021845 to YK), by a 2013 Research Grant from Kangwon National University to YK, by Korea Basic Science Institute grant (T32611 to SK) and by HD037105 to MEB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments: We thank Dr. Kye-Young Kim (NIH) for help with pathway analysis. The authors have declared that no competing interests exist. Author Contributions: Conceived and designed the experiments: YK BJH. Performed the experiments: S-HK OKP SN JK BJH YK. Analyzed the data: S-HK OKP SN JK BJH YK. Contributed reagents/materials/analysis tools: YK MEB BJH. Wrote the paper: YK MEB BJH.
Funding AgencyGrant Number
National Research Foundation of Korea (NRF)2011-0021845
Kangwon National UniversityUNSPECIFIED
Korea Basic Science InstituteT32611
Issue or Number:7
PubMed Central ID:PMC4106859
Record Number:CaltechAUTHORS:20140828-084522656
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Official Citation:Kwon S-H, Park OK, Nie S, Kwak J, Hwang BJ, et al. (2014) Bioinformatic Analysis of Nematode Migration-Associated Genes Identifies Novel Vertebrate Neural Crest Markers. PLoS ONE 9(7): e103024. doi:10.1371/journal.pone.0103024
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:49012
Deposited By: Jason Perez
Deposited On:28 Aug 2014 20:32
Last Modified:10 Nov 2021 18:38

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