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Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium

Cao, Hung and Yu, Fei and Zhao, Yu and Zhang, Xiaoxiao and Tai, Joyce and Lee, Juhyun and Darehzerenski, Ali and Bersohn, Malcolm and Lien, Ching-Ling and Chi, Neil C. and Tai, Yu-Chong and Hsiai, Tzung K. (2014) Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium. Integrative Biology, 6 (8). pp. 789-795. ISSN 1757-9694. PMCID PMC4124744. http://resolver.caltech.edu/CaltechAUTHORS:20140902-083854858

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Abstract

Understanding the regenerative capacity of small vertebrate models has provided new insights into the plasticity of injured myocardium. Here, we demonstrate the application of flexible microelectrode arrays (MEAs) in elucidating electrophysiological phenotypes of zebrafish and neonatal mouse models of heart regeneration. The 4-electrode MEA membranes were designed to detect electrical signals in the aquatic environment. They were micro-fabricated to adhere to the non-planar body surface of zebrafish and neonatal mice. The acquired signals were processed to display an electrocardiogram (ECG) with high signal-to-noise-ratios, and were validated via the use of conventional micro-needle electrodes. The 4-channel MEA provided signal stability and spatial resolution, revealing the site-specific electrical injury currents such as ST-depression in response to ventricular cryo-injury. Thus, our polymer-based and wearable MEA membranes provided electrophysiological insights into long-term conduction phenotypes for small vertebral models of heart injury and regeneration with a translational implication for monitoring cardiac patients.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1039/c4ib00052hDOIArticle
http://pubs.rsc.org/en/Content/ArticleLanding/2014/IB/C4IB00052H#!divAbstractPublisherArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2014 The Royal Society of Chemistry. Received 11th March 2014. Accepted 15th May 2014. First published online 16 May 2014. These studies were supported by National Institutes of Health HL-068689 (T.K.H.), HL-083015 (T.K.H.), HD069305-01 (N.C.C., T.K.H.), 1R01HL111437-01 (T.K.H., N.C.C.), and R01HL096121-03 (C.L.L.). No competing financial interests exist.
Funders:
Funding AgencyGrant Number
NIHHL-068689
NIHHL-083015
NIHHD069305-01
NIH1R01HL111437-01
NIHR01HL096121-03
PubMed Central ID:PMC4124744
Record Number:CaltechAUTHORS:20140902-083854858
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140902-083854858
Official Citation:Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium Hung Cao, Fei Yu, Yu Zhao, Xiaoxiao Zhang, Joyce Tai, Juhyun Lee, Ali Darehzereshki, Malcolm Bersohn, Ching-Ling Lien, Neil C. Chi, Yu-Chong Tai and Tzung K. Hsiai Integr. Biol., 2014, 6, 789-795 DOI: 10.1039/C4IB00052H
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:49087
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:02 Sep 2014 16:21
Last Modified:17 May 2017 21:28

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