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The enzymatic synthesis of protein. I. The sythesizing action of pepsin

Wasteneys, Hardolph and Borsook, Henry (1924) The enzymatic synthesis of protein. I. The sythesizing action of pepsin. Journal of Biological Chemistry, 62 (1). pp. 15-29. ISSN 0021-9258.

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A condition in which a synthesis of protein-like material occurs, was first arranged in 1886 by Danilewski (1) who observed the formation of a precipitate when stomach extract was added to a concentrated solution of the products of peptic hydrolysis. He considered the causative agent to be an enzyme, because precipitation did not occur if the stomach extract had been previously heated to 100°C. This result was confirmed in 1895 by Okunew. Both Danilewski and Okunew concluded that the reaction involved synthesis of the products of protein decomposition into a more composite molecule approaching in complexity a native protein.

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Additional Information:© 1924 American Society for Biochemistry and Molecular Biology. Received for publication, July 18, 1924.
Issue or Number:1
Record Number:CaltechAUTHORS:20140902-141818800
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:49139
Deposited By: Tony Diaz
Deposited On:03 Sep 2014 16:34
Last Modified:03 Oct 2019 07:11

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