Yui, Mary A. and Rothenberg, Ellen V. (2014) Developmental gene networks: a triathlon on the course to T cell identity. Nature Reviews. Immunology, 14 (8). pp. 529-545. ISSN 1474-1733. PMCID PMC4153685. https://resolver.caltech.edu/CaltechAUTHORS:20140903-154240690
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Abstract
Cells acquire their ultimate identities by activating combinations of transcription factors that initiate and sustain expression of the appropriate cell type-specific genes. T cell development depends on the progression of progenitor cells through three major phases, each of which is associated with distinct transcription factor ensembles that control the recruitment of these cells to the thymus, their proliferation, lineage commitment and responsiveness to T cell receptor signals, all before the allocation of cells to particular effector programmes. All three phases are essential for proper T cell development, as are the mechanisms that determine the boundaries between each phase. Cells that fail to shut off one set of regulators before the next gene network phase is activated are predisposed to leukaemic transformation.
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Additional Information: | © 2014 Macmillan Publishers Limited. Published online 25 July 2014. The authors apologize to colleagues whose work helped to inspire this Review but could not be cited due to space constraints. The authors thank present and former members of their group whose published and unpublished data, as well as helpful discussion, shaped the ideas presented here. The authors gratefully acknowledge support from the US National Institutes of Health (NIH grant AI064590 to M.A.Y., and AI083514, AI095943 and HD076915 to E.V.R.) and the Albert Billings Ruddock Professorship (to E.V.R). Competing interests statement: The authors declare no competing interests. | ||||||||||||
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Issue or Number: | 8 | ||||||||||||
PubMed Central ID: | PMC4153685 | ||||||||||||
Record Number: | CaltechAUTHORS:20140903-154240690 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20140903-154240690 | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 49215 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Tony Diaz | ||||||||||||
Deposited On: | 03 Sep 2014 22:54 | ||||||||||||
Last Modified: | 15 Apr 2020 22:00 |
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