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Developmental gene networks: a triathlon on the course to T cell identity

Yui, Mary A. and Rothenberg, Ellen V. (2014) Developmental gene networks: a triathlon on the course to T cell identity. Nature Reviews. Immunology, 14 (8). pp. 529-545. ISSN 1474-1733. PMCID PMC4153685. https://resolver.caltech.edu/CaltechAUTHORS:20140903-154240690

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Abstract

Cells acquire their ultimate identities by activating combinations of transcription factors that initiate and sustain expression of the appropriate cell type-specific genes. T cell development depends on the progression of progenitor cells through three major phases, each of which is associated with distinct transcription factor ensembles that control the recruitment of these cells to the thymus, their proliferation, lineage commitment and responsiveness to T cell receptor signals, all before the allocation of cells to particular effector programmes. All three phases are essential for proper T cell development, as are the mechanisms that determine the boundaries between each phase. Cells that fail to shut off one set of regulators before the next gene network phase is activated are predisposed to leukaemic transformation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/nri3702DOIArticle
http://www.nature.com/nri/journal/v14/n8/full/nri3702.htmlPublisherArticle
http://rdcu.be/cmoXPublisherFree ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153685/PubMed CentralArticle
ORCID:
AuthorORCID
Yui, Mary A.0000-0002-3136-2181
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2014 Macmillan Publishers Limited. Published online 25 July 2014. The authors apologize to colleagues whose work helped to inspire this Review but could not be cited due to space constraints. The authors thank present and former members of their group whose published and unpublished data, as well as helpful discussion, shaped the ideas presented here. The authors gratefully acknowledge support from the US National Institutes of Health (NIH grant AI064590 to M.A.Y., and AI083514, AI095943 and HD076915 to E.V.R.) and the Albert Billings Ruddock Professorship (to E.V.R). Competing interests statement: The authors declare no competing interests.
Funders:
Funding AgencyGrant Number
NIHAI064590
NIHAI083514
NIHAI095943
NIHHD076915
Albert Billings Ruddock ProfessorshipUNSPECIFIED
Issue or Number:8
PubMed Central ID:PMC4153685
Record Number:CaltechAUTHORS:20140903-154240690
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140903-154240690
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:49215
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Sep 2014 22:54
Last Modified:03 Oct 2019 07:11

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