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Formation and removal of alkylthiolate self-assembled monolayers on gold in aqueous solutions

Canaria, Christie A. and So, Jonathan and Maloney, James R. and Yu, C. J. and Smith, Jeffrey O. and Roukes, Michael L. and Fraser, Scott E. and Lansford, Rusty (2006) Formation and removal of alkylthiolate self-assembled monolayers on gold in aqueous solutions. Lab on a Chip, 6 (2). pp. 289-295. ISSN 1473-0197. doi:10.1039/b510661c.

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We report the development of novel reagents and approaches for generating recyclable biosensors. The use of aqueous media for the formation of protein binding alkylthiolate monolayers on Au surfaces results in accelerated alkylthiolate monolayer formation and improvement in monolayer integrity as visualized by fluorescence microscopy and CV techniques. We have also developed an electrocleaning protocol that is compatible with microfluidics devices, and this technique serves as an on-chip method for cleaning Au substrates both before and after monolayer formation. The techniques for the formation and dissociation of biotinylated SAMs from aqueous solvents reported here may be applied towards the development of Au-based sensor devices and microfluidics chips in the future. A potential use of these devices includes the specific capture and triggered release of target cells, proteins, or small molecules from liquid samples.

Item Type:Article
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URLURL TypeDescription
Roukes, Michael L.0000-0002-2916-6026
Fraser, Scott E.0000-0002-5377-0223
Lansford, Rusty0000-0002-2159-3699
Additional Information:© The Royal Society of Chemistry 2006 Received 26th July 2005, Accepted 6th December 2005. First published on the web 3rd January 2006 This research was funded under DARPA grant MLR.00018-3-AFOSR.000019 and RDL.NASA.000143. The authors thank Blake Axelrod, Jessica Arlett, and Melaku Muluneh for their assistance in materials fabrication. C.A.C. thanks John Keith and Brad Cenko for helpful discussions.
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Air Force Office of Scientific Research (AFOSR)MLR.00018-3-AFOSR.000019
Issue or Number:2
Record Number:CaltechAUTHORS:CANloac06
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4961
Deposited By: Archive Administrator
Deposited On:15 Sep 2006
Last Modified:08 Nov 2021 20:21

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