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The Opisthorchis viverrini genome provides insights into life in the bile duct

Young, Neil D. and Nagarajan, Niranjan and Lin, Suling Joyce and Korhonen, Pasi K. and Jex, Aaron R. and Hall, Ross S. and Safavi-Hemami, Helena and Kaewkong, Worasak and Bertrand, Denis and Gao, Song and Seet, Qihui and Wongkham, Sopit and Teh, Bin Tean and Wongkham, Chaisiri and Intapan, Pewpan Maleewong and Maleewong, Wanchai and Yang, Xinhua and Hu, Min and Wang, Zuo and Hofmann, Andreas and Sternberg, Paul W. and Tan, Patrick and Wang, Jun and Gasser, Robin B. (2014) The Opisthorchis viverrini genome provides insights into life in the bile duct. Nature Communications, 5 (7). Art. No. 4378. ISSN 2041-1723. PMCID PMC4104445. https://resolver.caltech.edu/CaltechAUTHORS:20140912-092833842

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Abstract

Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5 Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/ncomms5378DOIArticle
http://www.nature.com/ncomms/2014/140709/ncomms5378/full/ncomms5378.htmlPublisherArticle
http://www.nature.com/ncomms/2014/140709/ncomms5378/full/ncomms5378.html#supplementary-informationPublisherSupplementary Information
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104445/PubMed CentralArticle
ORCID:
AuthorORCID
Gao, Song0000-0001-7427-6681
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2014 The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. Received 3 March 2014; Accepted 11 June 2014; Published 9 July 2014. We thank the staff of BGI-Shenzhen for their contributions. This project was funded by the Australian Research Council, the National Health and Medical Research Council (NHMRC) of Australia and BGI-Shenzhen (R.B.G.). Other support from the Alexander von Humboldt Foundation, Melbourne Water Corporation (R.B.G.) and Genome Institute of Singapore (P.T.) is gratefully acknowledged. This project was also supported by a Victorian Life Sciences Computation Initiative (grant number VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government. N.D.Y. holds an NHMRC Early Career Research Fellowship. P.W.S. thanks the Howard Hughes Medical Institute (HHMI) and the National Institutes of Health (NIH). We would specifically like to acknowledge the research scientists that developed the programs used in this study. Given restrictions on the number of publications that could be cited, we were unable to include all original articles in the methods section. Instead, we have included links to their respective websites. This paper is dedicated to the memory of Eduard Gasser.
Funders:
Funding AgencyGrant Number
Australian Research CouncilUNSPECIFIED
National Health and Medical Research Council (NHMRC) of AustraliaUNSPECIFIED
BGI-ShenzhenUNSPECIFIED
Alexander von Humboldt FoundationUNSPECIFIED
Melbourne Water CorporationUNSPECIFIED
Genome Institute of SingaporeUNSPECIFIED
Victorian Life Sciences Computation InitiativeVR0007
NHMRC Early Career Research FellowshipUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NIHUNSPECIFIED
Subject Keywords:Biological sciences; Evolution; Genetics
Issue or Number:7
PubMed Central ID:PMC4104445
Record Number:CaltechAUTHORS:20140912-092833842
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140912-092833842
Official Citation:Young, N. D., Nagarajan, N., Lin, S. J., Korhonen, P. K., Jex, A. R., Hall, R. S., . . . Gasser, R. B. (2014). The Opisthorchis viverrini genome provides insights into life in the bile duct. [Article]. Nat Commun, 5. doi: 10.1038/ncomms5378
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:49646
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:12 Sep 2014 23:04
Last Modified:09 Mar 2020 13:18

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