Valentino, J. P. and Troian, S. M. and Wagner, S. (2005) Microfluidic detection and analysis by integration of evanescent wave sensing with thermocapillary actuation. In: Proceedings of the 18th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2005), Miami, FL, 30 Jan.-3 Feb. 2005. IEEE , Los Alamitos, CA, pp. 730-733. ISBN 0-7803-8732-5. https://resolver.caltech.edu/CaltechAUTHORS:VALmems05
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Abstract
An integrated system capable of microfluidic actuation, detection and sensing is described which combines evanescent wave sensing with thermocapillary manipulation. Liquid droplets or streams transported across the beam path of a planar thin film waveguide, which encapsulates the microheater array, induce attenuation of the propagating waveguide modes. The attenuated signal is used to monitor droplet location, dye concentration in aqueous solutions and reaction kinetics for enzymatic hydrolysis of the sugar X-galactose by beta-galactosidase.
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| Additional Information: | This work was funded by the NASA Microgravity Fluid Physics Program and the US Army TACOM-ARDEC. JPV wishes to thank Dr. P. K. Tien of Bell Labs for helpful discussions. SMT gratefully acknowledges the Moore Distinguished Scholar Program at Caltech, where she is currently on leave, for the generous hospitality and financial support extended during her stay. | ||||||
| Group: | GALCIT | ||||||
| Subject Keywords: | biosensors; micromanipulators; enzymatic hydrolysis; evanescent wave sensing; microfluidic analysis; microheater array; planar thin film waveguide; reaction kinetics; thermocapillary actuation; thermocapillary manipulation | ||||||
| DOI: | 10.1109/MEMSYS.2005.1454033 | ||||||
| Record Number: | CaltechAUTHORS:VALmems05 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:VALmems05 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 4967 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Archive Administrator | ||||||
| Deposited On: | 18 Sep 2006 | ||||||
| Last Modified: | 08 Nov 2021 20:21 |
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