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"Ultra-Clean" Isotope Dilution/Mass Spectrometric Analyses for Lead in Human Blood Plasma Indicate That Most Reported Values Are Artificially High

Everson, Joel and Patterson, C. C. (1980) "Ultra-Clean" Isotope Dilution/Mass Spectrometric Analyses for Lead in Human Blood Plasma Indicate That Most Reported Values Are Artificially High. Clinical Chemistry, 26 (11). pp. 1603-1607. ISSN 0009-9147.

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We measured lead concentrations in venous blood plasma from two subjects, one having a typical exposure and the other a high exposure to lead. Our preliminary data, obtained by isotope dilution/mass spectrometric techniques in an ultra-clean laboratory, show lead concentrations of 0.02 µg/L and 2 µg/L, respectively, in their blood plasma, and 110 µg/L and 800 µg/L, respectively, in samples of whole blood. These results indicate that plasma lead concentrations previously reported have been overestimated by a large factor, and that further improvements in analytical procedures are needed in most laboratories before data on lead concentrations in blood plasma can be properly interpreted. Our preliminary data indicate a positive correlation between lead intake and lead concentrations in blood plasma.

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Additional Information:© 1980 The American Association for Clinical Chemistry. Received May 9, 1980; accepted June 30, 1980. We gratefully acknowledge support by the Treadway Trust Fund. This reeearch was supported in part by NSF grant DEB73-01306 A01. Dr. C. C. Culver provided invaluable assistance in locating an occupationally exposed subject with high blood-lead concentrations. D. Settle, M. Burnett, and D. Northfelt aided in developing procedures for the collection and analysis of samples. Nurse R. Canby carried out the venipunctures required for sample collection.
Funding AgencyGrant Number
Treadway Trust FundUNSPECIFIED
NSFDEB73-01306 A01
Subject Keywords:trace elements, analytical error, from contaminants, variation, source of toxicology
Issue or Number:11
Record Number:CaltechAUTHORS:20140915-104230228
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Official Citation:J Everson and C C Patterson "Ultra-clean" isotope diultion/mass spectrometic analyses for lead in human blood plasma indicated that most reported values are artificially high. Clinical Chemistry 1980; v. 26, p.1603-7
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:49700
Deposited By: Ruth Sustaita
Deposited On:15 Sep 2014 17:57
Last Modified:03 Oct 2019 07:16

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