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Health effects of subchronic exposure to low levels of wood smoke in rats

Tesfaigzi, Yohannes and Singh, Shashibhushan P. and Foster, Jennifer E. and Kubatko, Justin and Barr, Edward B. and Fine, Philip M. and McDonald, Jacob D. and Hahn, Fletcher F. and Mauderly, Joe L. (2002) Health effects of subchronic exposure to low levels of wood smoke in rats. Toxicological Sciences, 65 (1). pp. 115-125. ISSN 1096-6080. https://resolver.caltech.edu/CaltechAUTHORS:TESts02

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Abstract

Wood smoke is a significant source of air pollution in many parts of the United States, and epidemiological data suggest a causal relationship between elevated wood smoke levels and health effects. The present study was designed to provide information on the potential respiratory health responses to subchronic wood smoke exposures in a Native American community in New Mexico. Therefore, this study used the same type of wood under similar burning conditions and wood smoke particle concentrations to mimic the conditions observed in this community. Brown Norway rats were exposed 3 h/day, 5 days/week for 4 or 12 weeks to air as control, or to 1 or 10 mg/m^3 concentrations of wood smoke particles from pinus edulis. The wood smoke consisted of fine particles (< 1 µm) that formed larger chains and aggregates having a size distribution of 63–74% in the < 1-µm fraction and 26–37% in the > 1-µm fraction. The particle-bound material was primarily composed of carbon, and the majority of identified organic compounds consisted of sugar and lignin derivatives. Pulmonary function, specifically carbon monoxide-diffusing capacity and pulmonary resistance, was somewhat affected in the high-exposure group. Mild chronic inflammation and squamous metaplasia were observed in the larynx of the exposed groups. The severity of alveolar macrophage hyperplasia and pigmentation increased with smoke concentration and length of exposure, and the alveolar septae were slightly thickened. The content of mucous cells lining the airways changed from Periodic Acid Schiff- to Alcian Blue-positive material in the low-exposure group after 90 days. Together, these observations suggest that exposure to wood smoke caused minor but significant changes in Brown Norway rats. Further studies are needed to establish whether exposure to wood smoke exacerbates asthmalike symptoms that resemble those described for children living in homes using wood stoves for heating and cooking.


Item Type:Article
Additional Information:Copyright © 2002 by the Society of Toxicology. Reprinted with permission. Received May 16, 2001; accepted September 24, 2001. The authors thank Yoneko Knighton for preparing and staining the tissue samples and Lee Blair, Mark Fischer, and Leigh Schutzberger for excellent technical assistance. Lovelace Respiratory Research Institute is fully accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care International. Research conducted on this study was sponsored by the National Environmental Respiratory Center (NERC) with support from multiple government and industry sponsors., including the U. S. Environmental Protection Agency. This paper is not intended to represent the views or policies of any NERC sponsor.
Subject Keywords:wood smoke; particles; chemical composition; rat; pulmonary function; histopathology; cytokines; lymphocytes
Issue or Number:1
Record Number:CaltechAUTHORS:TESts02
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:TESts02
Alternative URL:http://toxsci.oxfordjournals.org/cgi/content/abstract/65/1/115
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5008
Collection:CaltechAUTHORS
Deposited By: Lindsay Cleary
Deposited On:19 Sep 2006
Last Modified:02 Oct 2019 23:18

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