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Mitochondrial genomes of Trichinella species and genotypes – a basis for diagnosis, and systematic and epidemiological explorations

Mohandas, Namitha and Pozio, Edoardo and La Rosa, Giuseppe and Korhonen, Pasi K. and Young, Neil D. and Koehler, Anson V. and Hall, Ross S. and Sternberg, Paul W. and Boag, Peter R. and Jex, Aaron R. and Chang, Bill and Gasser, Robin B. (2014) Mitochondrial genomes of Trichinella species and genotypes – a basis for diagnosis, and systematic and epidemiological explorations. International Journal for Parasitology, 44 (14). pp. 1073-1080. ISSN 0020-7519. https://resolver.caltech.edu/CaltechAUTHORS:20140929-115146927

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Abstract

In the present study we sequenced or re-sequenced, assembled and annotated 15 mitochondrial genomes representing the 12 currently recognised taxa of Trichinella using a deep sequencing-coupled approach. We then defined and compared the gene order in individual mitochondrial genomes (∼14 to 17.7 kb), evaluated genetic differences among species/genotypes and re-assessed the relationships among these taxa using the mitochondrial nucleic acid or amino acid sequence data sets. In addition, a rich source of mitochondrial genetic markers was defined that could be used in future systematic, epidemiological and population genetic studies of Trichinella. The sequencing-bioinformatic approach employed herein should be applicable to a wide range of eukaryotic parasites.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.ijpara.2014.08.010DOIArticle
http://www.sciencedirect.com/science/article/pii/S002075191400232XPublisherArticle
ORCID:
AuthorORCID
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2014 Published by Elsevier Ltd. on behalf of Australian Society for Parasitology Inc. Received 24 June 2014; Received in revised form 8 August 2014; Accepted 11 August 2014; Available online 21 September 2014. This project was funded through the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) of Australia (R.B.G. et al.) and DG SANCO of the European Commission; it was also supported by a Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0007 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia. Other support from the Australian Academy of Science, Alexander von Humboldt Foundation, Germany, and Melbourne Water Corporation, Australia, is gratefully acknowledged. PWS is an Investigator with the Howard Hughes Medical Institute, USA. N.D.Y. is an NHMRC Early Career Research Fellow (ECRF).
Funders:
Funding AgencyGrant Number
Australian Research Council (ARC)UNSPECIFIED
National Health and Medical Research Council (NHMRC) of AustraliaUNSPECIFIED
European Commission DG SANCOUNSPECIFIED
Victorian Life Sciences Computation Initiative (VLSCI)VR0007
Australian Academy of ScienceUNSPECIFIED
Alexander von Humboldt FoundationUNSPECIFIED
Melbourne Water Corporation, AustraliaUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:Trichinella/trichinellosis; Deep sequencing; Bioinformatics; Mitochondrial genome; Genetic relationships; Systematics; Population genetics; Epidemiology
Issue or Number:14
Record Number:CaltechAUTHORS:20140929-115146927
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20140929-115146927
Official Citation:Namitha Mohandas, Edoardo Pozio, Giuseppe La Rosa, Pasi K. Korhonen, Neil D. Young, Anson V. Koehler, Ross S. Hall, Paul W. Sternberg, Peter R. Boag, Aaron R. Jex, Bill C.H. Chang, Robin B. Gasser, Mitochondrial genomes of Trichinella species and genotypes – a basis for diagnosis, and systematic and epidemiological explorations, International Journal for Parasitology, Volume 44, Issue 14, December 2014, Pages 1073-1080, ISSN 0020-7519, http://dx.doi.org/10.1016/j.ijpara.2014.08.010. (http://www.sciencedirect.com/science/article/pii/S002075191400232X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:50097
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:29 Sep 2014 19:51
Last Modified:03 Oct 2019 07:20

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