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Finding the Missing Links among Metabolites, Microbes, and the Host

Dorrestein, Pieter C. and Mazmanian, Sarkis K. and Knight, Rob (2014) Finding the Missing Links among Metabolites, Microbes, and the Host. Immunity, 40 (6). pp. 824-832. ISSN 1074-7613. PMCID PMC4503329. doi:10.1016/j.immuni.2014.05.015.

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The unexpected diversity of the human microbiome and metabolome far exceeds the complexity of the human genome. Although we now understand microbial taxonomic and genetic repertoires in some populations, we are just beginning to assemble the necessary computational and experimental tools to understand the metabolome in comparable detail. However, even with the limited current state of knowledge, individual connections between microbes and metabolites, between microbes and immune function, and between metabolites and immune function are being established. Here, we provide our perspective on these connections and outline a systematic research program that could turn these individual links into a broader network that allows us to understand how these components interact. This program will enable us to exploit connections among the microbiome, metabolome, and host immune system to maintain health and perhaps help us understand how to reverse the processes that lead to a wide range of immune and other diseases.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Mazmanian, Sarkis K.0000-0003-2713-1513
Knight, Rob0000-0002-0975-9019
Alternate Title:From microbiomes to metabolomes to function during host-microbial interactions
Additional Information:© 2014 Elsevier Inc. Available online 19 June 2014.
Issue or Number:6
PubMed Central ID:PMC4503329
Record Number:CaltechAUTHORS:20141002-114943526
Persistent URL:
Official Citation:Pieter C. Dorrestein, Sarkis K. Mazmanian, Rob Knight, Finding the Missing Links among Metabolites, Microbes, and the Host, Immunity, Volume 40, Issue 6, 19 June 2014, Pages 824-832, ISSN 1074-7613, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:50173
Deposited By: Ruth Sustaita
Deposited On:02 Oct 2014 21:32
Last Modified:10 Nov 2021 18:52

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