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The Parietal Reach Region Selectively Anti-Synchronizes with Dorsal Premotor Cortex during Planning

Stetson, Chess and Andersen, Richard A. (2014) The Parietal Reach Region Selectively Anti-Synchronizes with Dorsal Premotor Cortex during Planning. Journal of Neuroscience, 34 (36). pp. 11948-11958. ISSN 0270-6474. PMCID PMC4152603. https://resolver.caltech.edu/CaltechAUTHORS:20141009-090027491

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Abstract

Recent reports have indicated that oscillations shared across distant cortical regions can enhance their connectivity, but do coherent oscillations ever diminish connectivity? We investigated oscillatory activity in two distinct reach-related regions in the awake behaving monkey (Macaca mulatta): the parietal reach region (PRR) and the dorsal premotor cortex (PMd). PRR and PMd were found to oscillate at similar frequencies (beta, 15–30 Hz) during periods of fixation and movement planning. At first glance, the stronger oscillator of the two, PRR, would seem to drive the weaker, PMd. However, a more fine-grained measure, the partial spike-field coherence, revealed a different relationship. Relative to global beta-band activity in the brain, action potentials in PRR anti-synchronize with PMd oscillations. These data suggest that, rather than driving PMd during planning, PRR neurons fire in such a way that they are less likely to communicate information to PMd.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1523/JNEUROSCI.0097-14.2014DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152603/PubMed CentralArticle
ORCID:
AuthorORCID
Stetson, Chess0000-0003-0549-8197
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2014 the authors. For the first six months after publication SfN’s license will be exclusive. Beginning six months after publication SfN’s license will be nonexclusive and SfN grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ Received Jan. 1, 2014; revised May 27, 2014; accepted June 17, 2014. This work was supported by the Swartz Foundation, the National Eye Institutes (R01 EY007492), and the Conte Foundation (P50 MH094258A). We thank Linus Schumacher, Xoana Troncoso, Cevat Ustun, Boris Revechkis, Vasileios Christopoulos, and Arnulf Graf for helpful discussions; Viktor Shcherbatyuk for computer support; Tessa Yao for administrative support; and Kelsie Pejsa and Carina Gonzalez for help with animal handling and training. Author contributions: C.S. and R.A.A. designed research; C.S. performed research; C.S. analyzed data; C.S. and R.A.A. wrote the paper. The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
Swartz FoundationUNSPECIFIED
NIHR01 EY007492
NIHP50 MH094258A
National Eye InstituteUNSPECIFIED
Subject Keywords:beta-band; coherence; local field potentials; parietal reach region; parietofrontal; spike-LFP coherence
Issue or Number:36
PubMed Central ID:PMC4152603
Record Number:CaltechAUTHORS:20141009-090027491
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141009-090027491
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:50296
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Oct 2014 21:20
Last Modified:31 Mar 2020 19:15

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