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Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice

Gallardo, Christian M. and Darvas, Martin and Oviatt, Mia and Chang, Chris H. and Michalik, Mateusz and Huddy, Timothy F. and Meyer, Emily and Shuster, Scott A. and Aguayo, Antonio and Hill, Elizabeth M. and Kiani, Kaun and Ikpeazu, Jonathan and Martinez, Johan S. and Purpura, Mari and Smit, Andrea N. and Patton, Danica and Mistlberger, Ralph E. and Palmiter, Richard D. and Steele, Andrew D. (2014) Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice. eLife, 3 . Art. No. e03781. ISSN 2050-084X. PMCID PMC4196120. https://resolver.caltech.edu/CaltechAUTHORS:20141013-130954074

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Abstract

Daily rhythms of food anticipatory activity (FAA) are regulated independently of the suprachiasmatic nucleus, which mediates entrainment of rhythms to light, but the neural circuits that establish FAA remain elusive. Here we show that mice lacking the dopamine D1 receptor (D1R KO mice), manifest greatly reduced FAA, whereas mice lacking the dopamine D2 receptor have normal FAA. To determine where dopamine exerts its effect, we limited expression of dopamine signaling to the dorsal striatum of dopamine-deficient mice; these mice developed FAA. Within the dorsal striatum, the daily rhythm of clock gene per2 expression was markedly suppressed in D1R KO mice. Pharmacological activation of D1R at the same time daily was sufficient to establish anticipatory activity in wild-type mice. These results demonstrate that dopamine signaling to D1R in the dorsal striatum plays an important role in manifestation of FAA, possibly by synchronizing circadian oscillators that modulate motivational processes and behavioral output.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://elifesciences.org/content/3/e03781PublisherArticle
http://dx.doi.org/10.7554/eLife.03781DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25217530/PubMed CentralArticle
http://elifesciences.org/highwire/filestream/16581/field_highwire_adjunct_files/0/elife03781_Supplemental_files.zipPublisherData Supplement
Additional Information:© 2014, Gallardo et al. Received June 25, 2014. Accepted September 10, 2014. Published September 12, 2014. This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited. This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited. Funding was provided by the Broad Fellows Program in Brain Circuitry at Caltech, an Ellison Medical Foundation New Scholar Award to ADS, a Grants Program in Eating Disorders Research from the Klarman Family Foundation to ADS, a Claremont McKenna Interdisciplinary Science Scholarship to CHC, a HHMI summer fellowship to EM, an Natural Sciences and Engineering Research Council (Canada) operating grant to REM, and NSERC scholarships to MM and DFP, and a National Institutes of Health Center Grant P50 NS062684. We are grateful to members of the Palmiter laboratory and to Henry Lester, David Anderson, and Christof Koch (Caltech) for helpful advice. We are also grateful to Teagan Wall for assistance with Minimitter implantation surgery.
Funders:
Funding AgencyGrant Number
Caltech Broad Fellows Program in Brain CircuitryUNSPECIFIED
Ellison Medical FoundationUNSPECIFIED
Klarman Family Foundation Program in Eating Disorders ResearchUNSPECIFIED
Claremont-McKenna Interdisciplinary Science ScholarshipUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
NIHP50 NS062684
PubMed Central ID:PMC4196120
Record Number:CaltechAUTHORS:20141013-130954074
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141013-130954074
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:50354
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Oct 2014 23:10
Last Modified:03 Oct 2019 07:22

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