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Cancer immunotherapy and next-generation clinical immune assessment

Ma, Chao and Fan, Rong (2014) Cancer immunotherapy and next-generation clinical immune assessment. Frontiers in Oncology, 2014 . Art. No. 265. ISSN 2234-943X. PMCID PMC4173308. http://resolver.caltech.edu/CaltechAUTHORS:20141020-120021907

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Abstract

The interplay between cancerous cells and immune cells has always been an intriguing topic in medicine and biology. Cancer cells emerge from self-cells through a series of genetic mutations. They often retain self-cells’ capacity in being exempt from immune surveillance. Therefore, bringing cancer cells back under the radar of immune system has long been considered as a necessary step toward complete tumor eradication and long-term antitumor protection. Based on this rationale, a series of immunotherapies were designed and many have shown promising results. Some have gone through multiple stages of clinical trials. As a result, a successful immunotherapy is an intricate clinical procedure that affects the function of a myriad of cells. Only comprehensive studies that profile multiple aspects (e.g., cellular abundance, phenotypes, and functions) over time at the finest details can effectively monitor the convoluted immune response induced by therapy. Many recent technical developments aim to provide a solution for comprehensive clinical immune assessment.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.3389/fonc.2014.00265 DOIArticle
http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00265/impactPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25309877/PubMed CentralArticle
Additional Information:© 2014 Ma and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s)or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 22 July 2014; Accepted: 09 September 2014; Published online: 24 September 2014.
Subject Keywords:cancer immunotherapy; immune suppression; tumor immunity; immune assessment; single cell analysis; cytokine; functional heterogeneity; combinatory therapy; immune evasion; functional proteomics
PubMed Central ID:PMC4173308
Record Number:CaltechAUTHORS:20141020-120021907
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20141020-120021907
Official Citation:Ma C and Fan R(2014) Cancer immunotherapy and next-generation clinical immune assessment. Front. Oncol. 4:265. doi: 10.3389/fonc.2014.00265
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:50554
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:20 Oct 2014 21:20
Last Modified:03 Dec 2014 23:01

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