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Targeted Chemotherapy with Metal Complexes

Weidmann, Alyson G. and Komor, Alexis C. and Barton, Jacqueline K. (2014) Targeted Chemotherapy with Metal Complexes. Comments on Inorganic Chemistry, 34 (3-4). pp. 114-123. ISSN 0260-3594. PMCID PMC4309285. doi:10.1080/02603594.2014.890099. https://resolver.caltech.edu/CaltechAUTHORS:20141024-100939620

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Abstract

Classical chemotherapeutics, such as cisplatin and its analogues, have been highly successful in the clinic, yet improvements can certainly be made, given the significant side effects associated with the killing of healthy cells. Recent advances in the field of chemotherapy include the development of targeted anticancer agents, compounds that are directed towards a specific biomarker of cancer, with the hopes that such targeted therapies might have reduced side effects given their greater selectivity. Here we discuss several transition metal complexes that are tailored towards various biomolecules associated with cancer. Most notably, the success of rhodium metalloinsertors, which specifically bind to nucleic acid base mismatches in DNA, highlight the enormous potential of this exciting new strategy.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1080/02603594.2014.890099DOIArticle
http://www.tandfonline.com/doi/abs/10.1080/02603594.2014.890099PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309285/PubMed CentralArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2014 Taylor & Francis Group, LLC. Published online: 01 May 2014. We are grateful to the NIH (GM33309) for the long support of this work. In addition, we thank the NIH for a training grant to A.G.W., NSF for fellowship support for A.C.K., and the Moore Foundation for their support of the Caltech Chemistry Signaling Center.
Funders:
Funding AgencyGrant Number
NIHGM33309
NSFUNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Subject Keywords:bioinorganic, DNA mismatch repair, medicinal chemistry
Issue or Number:3-4
PubMed Central ID:PMC4309285
DOI:10.1080/02603594.2014.890099
Record Number:CaltechAUTHORS:20141024-100939620
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141024-100939620
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:50777
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Oct 2014 17:55
Last Modified:10 Nov 2021 19:00

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