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Cell death regulation in Drosophila: Conservation of mechanism and unique insights

Vernooy, Stephanie Y. and Copeland, Jeffrey and Ghaboosi, Nazli and Griffin, Erik E. and Yoo, Soon Ji and Hay, Bruce A. (2000) Cell death regulation in Drosophila: Conservation of mechanism and unique insights. Journal of Cell Biology, 150 (2). F69-F75. ISSN 0021-9525. PMCID PMC2180229. doi:10.1083/jcb.150.2.F69. https://resolver.caltech.edu/CaltechAUTHORS:VERjcb00

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Abstract

Programmed cell death, or apoptosis, is a genetically encoded form of cell suicide that results in the orderly death and phagocytic removal of excess, damaged, or dangerous cells during normal development and in the adult. The cellular machinery required to carry out apoptosis is present in most, if not all cells, but is only activated in cells instructed to die (for review see Jacobson et al. 1997). Here, we review cell death regulation in the fly in the context of a first pass look at the complete Drosophila genome and what is known about death regulation in other organisms, particularly worms and vertebrates.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1083/jcb.150.2.F69DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc2180229/PubMed CentralArticle
Additional Information:© 2000 The Rockefeller University Press. Submitted 15 June 2000;revised 21 June 2000;accepted 21 June 2000. This work was supported by grants to B.A. Hay from a Burroughs Wellcome Fund New Investigator Award in the Pharmacological Sciences, the Ellison Medical Foundation, and from the National Institutes of Health (No. GM057422-01). S.J. Yoo is supported by a postdoctoral fellowship from the Jane Coffin Childs Foundation.
Funders:
Funding AgencyGrant Number
Burroughs Wellcome FundUNSPECIFIED
Ellison Medical FoundationUNSPECIFIED
NIHGM057422-01
Jane Coffin Childs Memorial Fund for Medical ResearchUNSPECIFIED
Subject Keywords:BACULOVIRUS INHIBITOR; INDUCED APOPTOSIS; PROTEINS; CASPASE; FAMILY; GENE; MELANOGASTER; HOMOLOG; REAPER; GRIM
Issue or Number:2
PubMed Central ID:PMC2180229
DOI:10.1083/jcb.150.2.F69
Record Number:CaltechAUTHORS:VERjcb00
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:VERjcb00
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5078
Collection:CaltechAUTHORS
Deposited By: Lindsay Cleary
Deposited On:28 Sep 2006
Last Modified:08 Nov 2021 20:22

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