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Epigenetic regulation in neural crest development

Hu, Na and Strobl-Mazzulla, Pablo H. and Bronner, Marianne E. (2014) Epigenetic regulation in neural crest development. Developmental Biology, 396 (2). pp. 159-168. ISSN 0012-1606. PMCID PMC4261016. doi:10.1016/j.ydbio.2014.09.034.

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The neural crest is a migratory and multipotent cell population that plays a crucial role in many aspects of embryonic development. In all vertebrate embryos, these cells emerge from the dorsal neural tube then migrate long distances to different regions of the body, where they contribute to formation of many cell types and structures. These include much of the peripheral nervous system, craniofacial skeleton, smooth muscle, and pigmentation of the skin. The best-studied regulatory events guiding neural crest development are mediated by transcription factors and signaling molecules. In recent years, however, growing evidence supports an important role for epigenetic regulation as an additional mechanism for controlling the timing and level of gene expression at different stages of neural crest development. Here, we summarize the process of neural crest formation, with focus on the role of epigenetic regulation in neural crest specification, migration, and differentiation as well as in neural crest related birth defects and diseases.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Strobl-Mazzulla, Pablo H.0000-0003-0591-6168
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2014 Elsevier Inc. Received 20 March 2014; Received in revised form 17 September 2014; Accepted 25 September 2014; Available online 24 October 2014.
Subject Keywords:Neural crest; Epigenetic; Development
Issue or Number:2
PubMed Central ID:PMC4261016
Record Number:CaltechAUTHORS:20141110-080255491
Persistent URL:
Official Citation:Na Hu, Pablo H. Strobl-Mazzulla, Marianne E. Bronner, Epigenetic regulation in neural crest development, Developmental Biology, Volume 396, Issue 2, 15 December 2014, Pages 159-168, ISSN 0012-1606, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51478
Deposited By: Tony Diaz
Deposited On:10 Nov 2014 16:51
Last Modified:10 Nov 2021 19:11

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