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Dynamic Optimization of Odor Representations by Slow Temporal Patterning of Mitral Cell Activity

Friedrich, Rainer W. and Laurent, Gilles (2001) Dynamic Optimization of Odor Representations by Slow Temporal Patterning of Mitral Cell Activity. Science, 291 (5505). pp. 889-894. ISSN 0036-8075. doi:10.1126/science.291.5505.889. https://resolver.caltech.edu/CaltechAUTHORS:20141112-093451524

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Abstract

Mitral cells (MCs) in the olfactory bulb (OB) respond to odors with slow temporal firing patterns. The representation of each odor by activity patterns across the MC population thus changes continuously throughout a stimulus, in an odor-specific manner. In the zebrafish OB, we found that this distributed temporal patterning progressively reduced the similarity between ensemble representations of related odors, thereby making each odor's representation more specific over time. The tuning of individual MCs was not sharpened during this process. Hence, the individual responses of MCs did not become more specific, but the odor-coding MC assemblies changed such that their overlap decreased. This optimization of ensemble representations did not occur among olfactory afferents but resulted from OB circuit dynamics. Time can therefore gradually optimize stimulus representations in a sensory network.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.291.5505.889DOIArticle
http://www.sciencemag.org/content/291/5505/889PublisherArticle
ORCID:
AuthorORCID
Laurent, Gilles0000-0002-2296-114X
Additional Information:© 2001 American Association for the Advancement of Science. Received 12 September 2000; accepted 4 December 2000. We thank M. Welling, P. Perona, and members of the Laurent lab for discussion of multivariate analysis methods and M. Stopfer and E. Schuman for comments on the manuscript. Supported by the National Institute on Deafness and Other Communication Disorders, the Keck Foundation, and the McKnight Foundation (G.L.) and by fellowships from the Del Webb Fund (Caltech) and the Max-Planck-Society (R.W.F.).
Funders:
Funding AgencyGrant Number
National Institute on Deafness and Other Communication DisordersUNSPECIFIED
W. M. Keck FoundationUNSPECIFIED
McKnight FoundationUNSPECIFIED
Caltech Del Webb FundUNSPECIFIED
Max-Planck-SocietyUNSPECIFIED
Issue or Number:5505
DOI:10.1126/science.291.5505.889
Record Number:CaltechAUTHORS:20141112-093451524
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141112-093451524
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51636
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Nov 2014 21:51
Last Modified:10 Nov 2021 19:13

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