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Deciphering the Underlying Mechanism of Specification and Differentiation: The Sea Urchin Gene Regulatory Network

Ben-Tabou de-Leon, Smadar and Davidson, Eric H. (2006) Deciphering the Underlying Mechanism of Specification and Differentiation: The Sea Urchin Gene Regulatory Network. Science's STKE: signal transduction knowledge environment, 2006 (361). Art. No. pe 47. ISSN 1525-8882. doi:10.1126/stke.3612006pe47.

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A single cell, the fertilized egg, gives rise to a tremendous diversity of cell types to create the various tissues and organs that eventually form the adult body plan. The DNA can be thought of as both the hardware and the software of this developmental program, and it also serves a memory function to convey the program from one generation to the next. How this information is encoded and how this program is executed are two fundamental questions in biology. A first step toward answering these questions is to understand the mechanisms that control differential gene expression and lead to the formation of the body plan.

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Additional Information:© 2006 American Association for the Advancement of Science. Published 14 November 2006. We thank J. Smith, P. Oliveri, and V. Hinman for illuminating discussions, and A. Cameron and Shlomo Ben-Tabou de-Leon for critical evaluation of this manuscript. Smadar Ben-Tabou de-Leon was supported by the Rothschild fellowship and the International Human Frontier Science Program Organization.
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Rothschild FoundationUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Issue or Number:361
Record Number:CaltechAUTHORS:20141112-102325644
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Official Citation:S. Ben-Tabou de-Leon, E. H. Davidson, Deciphering the underlying mechanism of specification and differentiation: The sea urchin gene regulatory network. Sci. STKE 2006, pe47 (2006)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51642
Deposited By: Tony Diaz
Deposited On:12 Nov 2014 21:37
Last Modified:10 Nov 2021 19:13

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