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Dependence of Stem Cell Fate in Arabidopsis on a Feedback Loop Regulated by CLV3 Activity

Brand, Ulrike and Fletcher, Jennifer C. and Hobe, Martin and Meyerowitz, Elliot M. and Simon, Rüdiger (2000) Dependence of Stem Cell Fate in Arabidopsis on a Feedback Loop Regulated by CLV3 Activity. Science, 289 (5479). pp. 617-619. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141112-145026470

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Abstract

The fate of stem cells in plant meristems is governed by directional signaling systems that are regulated by negative feedback. In Arabidopsis thaliana, the CLAVATA(CLV) genes encode the essential components of a negative, stem cell–restricting pathway. We used transgenic plants overexpressing CLV3 to show that meristem cell accumulation and fate depends directly on the level of CLV3 activity and that CLV3 signaling occurs exclusively through a CLV1/CLV2 receptor kinase complex. We also demonstrate that the CLV pathway acts by repressing the activity of the transcription factor WUSCHEL, an element of the positive, stem cell–promoting pathway.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.sciencemag.org/content/289/5479/617.abstractPublisherArticle
http://dx.doi.org/10.1126/science.289.5479.617DOIArticle
ORCID:
AuthorORCID
Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 2000 American Association for the Advancement of Science. Received for publication 13 April 2000. Accepted for publication 1 June 2000. We thank N. Beinert and J. Wong for technical assistance and members of the Meyerowitz lab and the Simon lab for discussion. Supported by the NIH ( J.C.F.), the U.S. Department of Agriculture ( J.C.F.), the NSF (E.M.M.), Zeneca Seeds (E.M.M.), and the Deutsche Forschungsgemeinschaft through the Sonderforschungsbereich 243 (U.B., M.H., and R.S.).
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
U.S. Department of AgricultureUNSPECIFIED
NSFUNSPECIFIED
Zeneca SeedsUNSPECIFIED
Deutsche Forschungsgemeinschaft (DFG)243
Issue or Number:5479
Record Number:CaltechAUTHORS:20141112-145026470
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141112-145026470
Official Citation:Dependence of Stem Cell Fate in Arabidopsis on a Feedback Loop Regulated by CLV3 Activity Ulrike Brand, Jennifer C. Fletcher, Martin Hobe, Elliot M. Meyerowitz, and Rüdiger Simon Science 28 July 2000: 289 (5479), 617-619. [DOI:10.1126/science.289.5479.617]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51681
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Nov 2014 00:34
Last Modified:03 Oct 2019 07:35

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