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The Interface Between the Biological and Inorganic Worlds: Iron-Sulfur Metalloclusters

Rees, Douglas C. and Howard, James B. (2003) The Interface Between the Biological and Inorganic Worlds: Iron-Sulfur Metalloclusters. Science, 300 (5621). pp. 929-931. ISSN 0036-8075. doi:10.1126/science.1083075.

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Complex iron-sulfur metalloclusters form the active sites of the enzymes that catalyze redox transformations of N_2, CO, and H_2, which are likely components of Earth's primordial atmosphere. Although these centers reflect the organizational principles of simpler iron-sulfur clusters, they exhibit extensive elaborations that confer specific ligand-binding and catalytic properties. These changes were probably achieved through evolutionary processes, including the fusion of small clusters, the addition of new metals, and the development of cluster assembly pathways, driven by selective pressures resulting from changes in the chemical composition of the biosphere.

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Rees, Douglas C.0000-0003-4073-1185
Additional Information:© 2003 American Association for the Advancement of Science. We thank D. Newman for discussions. This work was supported in part by NIH grant GM45162. Because of the overview nature of this paper, references are not exhaustive and primarily serve as entry points to the relevant literature.
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Issue or Number:5621
Record Number:CaltechAUTHORS:20141112-145327502
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51683
Deposited By: Tony Diaz
Deposited On:13 Nov 2014 00:35
Last Modified:10 Nov 2021 19:14

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