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N-Cadherin, a Cell Adhesion Molecule Involved in Establishment of Embryonic Left-Right Asymmetry

García-Castro, Martin I. and Vielmetter, Eva and Bronner-Fraser, Marianne (2000) N-Cadherin, a Cell Adhesion Molecule Involved in Establishment of Embryonic Left-Right Asymmetry. Science, 288 (5468). pp. 1047-1051. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141113-071030883

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Abstract

Within the bilaterally symmetric vertebrate body plan, many organs develop asymmetrically. Here, it is demonstrated that a cell adhesion molecule, N-cadherin, is one of the earliest proteins to be asymmetrically expressed in the chicken embryo and that its activity is required during gastrulation for proper establishment of the left-right axis. Blocking N-cadherin function randomizes heart looping and alters the expression of Snail and Pitx2, later components of the molecular cascade that regulate left-right asymmetry. However, the expression of other components of this cascade (Nodal and Lefty) was unchanged after blocking N-cadherin function, suggesting the existence of parallel pathways in the establishment of left-right morphogenesis. Here, the results suggest that N-cadherin-mediated cell adhesion events are required for establishment of left-right asymmetry.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.sciencemag.org/content/288/5468/1047.abstractPublisherArticle
http://dx.doi.org/10.1126/science.288.5468.1047DOIArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2000 American Association for the Advancement of Science. 11 November 1999; accepted 5 April 2000. Supported by U.S. Public Health Service grant HD 15527 (M.B.-F.), American Heart Association 1140-FI1 (M.I.G-C.), and the Summer Undergraduate Research Fellowship, Caltech (E.V.). We thank C. Baker, A. Groves, C. LaBonne, and B. E. Murray for helpful discussions and comments and R. Velasco for help with sectioning.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)HD-15527
American Heart Association1140-FI1
Caltech Summer Undergraduate Research Fellowship (SURF)UNSPECIFIED
Issue or Number:5468
Record Number:CaltechAUTHORS:20141113-071030883
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141113-071030883
Official Citation:N-Cadherin, a Cell Adhesion Molecule Involved in Establishment of Embryonic Left-Right Asymmetry Martı́n I. Garcı́a-Castro, Eva Vielmetter, and Marianne Bronner-Fraser Science 12 May 2000: 288 (5468), 1047-1051. [DOI:10.1126/science.288.5468.1047]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51691
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Nov 2014 17:04
Last Modified:03 Oct 2019 07:35

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