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Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

Melov, Simon and Ravenscroft, Joanne and Malik, Sarwatt and Gill, Matt S. and Walker, David W. and Clayton, Peter E. and Wallace, Douglas C. and Malfroy, Bernard and Doctrow, Susan R. and Lithgow, Gordon J. (2000) Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics. Science, 289 (5484). pp. 1567-1569. ISSN 0036-8075. doi:10.1126/science.289.5484.1567.

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We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

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Additional Information:© 2000 American Association for the Advancement of Science. 27 March 2000; accepted 11 July 2000. We thank the Lithgow lab and A. Seyed Jazayeri-Dezfuly for critical and helpful discussions. M.S.G. is a Medical Research Council (MRC)-supported Training Fellow. D.W.W. is also supported by the MRC, and S. Malik was supported by Research into Aging. D.C.W. and S. Melov were supported in part by NIH grants AG-13154 and NS21328, awarded to D.C.W. All strains were obtained from the Caenorhabditis Genetics Center.
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Medical Research Council (MRC)UNSPECIFIED
Research into AgingUNSPECIFIED
Issue or Number:5484
Record Number:CaltechAUTHORS:20141113-130428662
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Official Citation:Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics Simon Melov, Joanne Ravenscroft, Sarwatt Malik, Matt S. Gill, David W. Walker, Peter E. Clayton, Douglas C. Wallace, Bernard Malfroy, Susan R. Doctrow, and Gordon J. Lithgow Science 1 September 2000: 289 (5484), 1567-1569. [DOI:10.1126/science.289.5484.1567]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51713
Deposited By: Ruth Sustaita
Deposited On:14 Nov 2014 17:00
Last Modified:10 Nov 2021 19:14

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