Rubin, Gerald M. and Hay, Bruce A. (2000) Comparative Genomics of the Eukaryotes. Science, 287 (5461). pp. 2204-2215. ISSN 0036-8075. PMCID PMC2754258. doi:10.1126/science.287.5461.2204. https://resolver.caltech.edu/CaltechAUTHORS:20141114-074753633
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Abstract
A comparative analysis of the genomes ofDrosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae—and the proteins they are predicted to encode—was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2000 American Association for the Advancement of Science. The many participants from academic institutions are grateful for their various sources of support. Participants from the Berkeley Drosophila Genome Project are supported by NIH grant P50HG00750 (G.M.R.) and grant P4IHG00739 (W.M.G.). | |||||||||
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| Issue or Number: | 5461 | |||||||||
| PubMed Central ID: | PMC2754258 | |||||||||
| DOI: | 10.1126/science.287.5461.2204 | |||||||||
| Record Number: | CaltechAUTHORS:20141114-074753633 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141114-074753633 | |||||||||
| Official Citation: | Comparative Genomics of the Eukaryotes. By Gerald M. Rubin, Mark D. Yandell, Jennifer R. Wortman, George L. Gabor, Miklos, Catherine R. Nelson, Iswar K. Hariharan, Mark E. Fortini, Peter W. Li, Rolf Apweiler, Wolfgang Fleischmann, J. Michael Cherry, Steven Henikoff, Marian P. Skupski, Sima Misra, Michael Ashburner, Ewan Birney, Mark S. Boguski, Thomas Brody, Peter Brokstein, Susan E. Celniker, Stephen A. Chervitz, David Coates, Anibal Cravchik, Andrei Gabrielian, Richard F. Galle, William M. Gelbart, Reed A. George, Lawrence S. B. Goldstein, Fangcheng Gong, Ping Guan, Nomi L. Harris, Bruce A. Hay, Roger A. Hoskins, Jiayin Li, Zhenya Li, Richard O. Hynes, S. J. M. Jones, Peter M. Kuehl, Bruno Lemaitre, J. Troy Littleton, Deborah K. Morrison, Chris Mungall, Patrick H. O'Farrell, Oxana K. Pickeral, Chris Shue, Leslie B. Vosshall, Jiong Zhang, Qi Zhao, Xiangqun H. Zheng, Fei Zhong, Wenyan Zhong, Richard Gibbs, J. Craig Venter, Mark D. Adams, Suzanna Lewis. Science 24 Mar 2000: 2204-2215; doi: 10.1126/science.287.5461.2204 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 51734 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 14 Nov 2014 16:24 | |||||||||
| Last Modified: | 10 Nov 2021 19:15 |
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