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A Gene Regulatory Network Subcircuit Drives a Dynamic Pattern of Gene Expression

Smith, Joel and Theodoris, Christina and Davidson, Eric H. (2007) A Gene Regulatory Network Subcircuit Drives a Dynamic Pattern of Gene Expression. Science, 318 (5851). pp. 794-797. ISSN 0036-8075. doi:10.1126/science.1146524.

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Early specification of endomesodermal territories in the sea urchin embryo depends on a moving torus of regulatory gene expression. We show how this dynamic patterning function is encoded in a gene regulatory network (GRN) subcircuit that includes the otx, wnt8, and blimp1 genes, the cis-regulatory control systems of which have all been experimentally defined. A cis-regulatory reconstruction experiment revealed that blimp1 autorepression accounts for progressive extinction of expression in the center of the torus, whereas its outward expansion follows reception of the Wnt8 ligand by adjacent cells. GRN circuitry thus controls not only static spatial assignment in development but also dynamic regulatory patterning.

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Additional Information:© 2007 American Association for the Advancement of Science. Received 15 June 2007; accepted 2 October 2007. Supported by a California Institute of Regenerative Medicine fellowship (J.S.) and by NIH grant HD-37105.
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California Institute of Regenerative MedicineUNSPECIFIED
Issue or Number:5851
Record Number:CaltechAUTHORS:20141114-081340988
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51739
Deposited By: Tony Diaz
Deposited On:14 Nov 2014 16:20
Last Modified:10 Nov 2021 19:15

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