Rubin, Gerald M. and Lewis, Edward B. (2000) A Brief History of Drosophila's Contributions to Genome Research. Science, 287 (5461). pp. 2216-2218. ISSN 0036-8075. doi:10.1126/science.287.5461.2216. https://resolver.caltech.edu/CaltechAUTHORS:20141117-084125979
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Abstract
The sequence of the Drosophila melanogaster genome presented in this issue of Science is the latest milestone in nine decades of research on this organism. Genetic and physical mapping, whole-genome mutational screens, and functional alteration of the genome by gene transfer were pioneered in metazoans with the use of this small fruit fly. Here we look at some of the instances in which work on Drosophila has led to major conceptual or technical breakthroughs in our understanding of animal genomes.
| Item Type: | Article | |||||||||
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| Additional Information: | 2000 American Association for the Advancement of Science. We thank our many colleagues for sharing their recollections, for checking facts in their old lab notebooks, and for helpful comments on the manuscript. Supported by grant HD06331 to E.L. from NIH. | |||||||||
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| Issue or Number: | 5461 | |||||||||
| DOI: | 10.1126/science.287.5461.2216 | |||||||||
| Record Number: | CaltechAUTHORS:20141117-084125979 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141117-084125979 | |||||||||
| Official Citation: | A Brief History of Drosophila's Contributions to Genome Research Gerald M. Rubin and Edward B. Lewis Science 24 March 2000: 287 (5461), 2216-2218. [DOI:10.1126/science.287.5461.2216] | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 51817 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 17 Nov 2014 21:34 | |||||||||
| Last Modified: | 10 Nov 2021 19:16 |
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