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TOPLESS Regulates Apical Embryonic Fate in Arabidopsis

Long, Jeff A. and Ohno, Carolyn and Smith, Zachery R. and Meyerowitz, Elliot M. (2006) TOPLESS Regulates Apical Embryonic Fate in Arabidopsis. Science, 312 (5779). pp. 1520-1523. ISSN 0036-8075. doi:10.1126/science.1123841.

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The embryos of seed plants develop with an apical shoot pole and a basal root pole. In Arabidopsis, the topless-1 (tpl-1) mutation transforms the shoot pole into a second root pole. Here, we show that TPL resembles known transcriptional corepressors and that tpl-1 acts as a dominant negative mutation for multiple TPL-related proteins. Mutations in the putative coactivator HISTONE ACETYLTRANSFERASE GNAT SUPERFAMILY1 suppress the tpl-1 phenotype. Mutations in HISTONE DEACETYLASE19, a putative corepressor, increase the penetrance of tpl-1 and display similar apical defects. These data point to a transcriptional repression mechanism that prevents root formation in the shoot pole during Arabidopsis embryogenesis.

Item Type:Article
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URLURL TypeDescription Online Material
Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 2006 American Association for the Advancement of Science. Received 14 December 2005; accepted 27 April 2006. We thank L. Jones, J. Nemhauser, and F. Wellmer for critical reading of the manuscript. We also thank M. Hannon and K. Shively for assistance with the tpl loss-of-function alleles and D. B. Vert and N. Geldner for technical assistance. This work was supported by a Helen Hay Whitney postdoctoral fellowship and by NIH grants GM072764 (to J.A.L.) and GM45697 (to E.M.M.).
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Helen Hay Whitney FoundationUNSPECIFIED
Issue or Number:5779
Record Number:CaltechAUTHORS:20141117-102347050
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Official Citation:TOPLESS Regulates Apical Embryonic Fate in Arabidopsis BY JEFF A. LONG, CAROLYN OHNO, ZACHERY R. SMITH, ELLIOT M. MEYEROWITZ Science 09 Jun 2006: Vol. 312, Issue 5779, pp. 1520-1523 DOI: 10.1126/science.1123841
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51835
Deposited By: Tony Diaz
Deposited On:17 Nov 2014 21:07
Last Modified:10 Nov 2021 19:16

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