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Oscillations and Sparsening of Odor Representations in the Mushroom Body

Perez-Orive, Javier and Mazor, Ofer and Turner, Glenn C. and Cassenaer, Stijn and Wilson, Rachel I. and Laurent, Gilles (2002) Oscillations and Sparsening of Odor Representations in the Mushroom Body. Science, 297 (5580). pp. 359-365. ISSN 0036-8075. doi:10.1126/science.1070502. https://resolver.caltech.edu/CaltechAUTHORS:20141117-103046995

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Abstract

In the insect olfactory system, oscillatory synchronization is functionally relevant and reflects the coherent activation of dynamic neural assemblies. We examined the role of such oscillatory synchronization in information transfer between networks in this system. The antennal lobe is the obligatory relay for olfactory afferent signals and generates oscillatory output. The mushroom body is responsible for formation and retrieval of olfactory and other memories. The format of odor representations differs significantly across these structures. Whereas representations are dense, dynamic, and seemingly redundant in the antennal lobe, they are sparse and carried by more selective neurons in the mushroom body. This transformation relies on a combination of oscillatory dynamics and intrinsic and circuit properties that act together to selectively filter and synthesize the output from the antennal lobe. These results provide direct support for the functional relevance of correlation codes and shed some light on the role of oscillatory synchronization in sensory networks.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1070502 DOIArticle
http://www.sciencemag.org/content/297/5580/359PublisherArticle
ORCID:
AuthorORCID
Laurent, Gilles0000-0002-2296-114X
Additional Information:© 2002 American Association for the Advancement of Science. 4 February 2002; accepted 31 May 2002. Supported by the National Institute for Deafness and other Communication Disorders; the National Science Foundation; the McKnight, Alfred P. Sloan, and Keck Foundations (G.L.); a Sloan and Swartz Foundations fellowship ( J.P.-O.); a Department of Defense National Defense Science and Engineering graduate fellowship (O.M.); the Elizabeth Ross fellowship (G.C.T.); and a Helen Hay Whitney postdoctoral fellowship (R.I.W.). We thank M. Westman for his intracellular PN data; C. Pouzat for help with spike sorting; S. Farivar for help with the immunocytochemistry; the Laurent Lab; E. Schuman, A. Siapas, and C. Mead for discussions; M. Roukes for help with silicon tetrodes; I. Lubenov and A. Siapas for help with wire tetrodes; M. Walsh for electronics; and the Caltech Biological Imaging Center for their resources and expertise. Multichannel silicon probes were provided by the University of Michigan Center for Neural Communication Technology sponsored by NIH NCRR grant no. P41-RR09754.
Funders:
Funding AgencyGrant Number
National Institute for Deafness and other Communication DisordersUNSPECIFIED
NSFUNSPECIFIED
McKnight FoundationUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
W. M. Keck FoundationUNSPECIFIED
Swartz FoundationUNSPECIFIED
National Defense Science and Engineering Graduate (NDSEG) FellowshipUNSPECIFIED
Elizabeth Ross fellowshipUNSPECIFIED
Helen Hay Whitney FoundationUNSPECIFIED
NIHP41-RR09754
Issue or Number:5580
DOI:10.1126/science.1070502
Record Number:CaltechAUTHORS:20141117-103046995
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141117-103046995
Official Citation:Perez-Orive, J., Mazor, O., Turner, G. C., Cassenaer, S., Wilson, R. I., & Laurent, G. (2002). Oscillations and Sparsening of Odor Representations in the Mushroom Body. Science, 297(5580), 359-365. doi: 10.1126/science.1070502
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51837
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:17 Nov 2014 20:47
Last Modified:10 Nov 2021 19:16

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