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Transcriptional Regulatory Networks in Saccharomyces cerevisiae

Lee, Tong Ihn and Rinaldi, Nicola J. and Robert, François and Odom, Duncan T. and Bar-Joseph, Ziv and Gerber, Georg K. and Hannett, Nancy M. and Harbison, Christopher T. and Thompson, Craig M. and Simon, Itamar and Zeitlinger, Julia and Jennings, Ezra G. and Murray, Heather L. and Gordon, D. Benjamin and Ren, Bing and Wyrick, John J. and Tagne, Jean Bosco and Volkert, Thomas L. and Fraenkel, Ernest and Gifford, David K. and Young, Richard A. (2002) Transcriptional Regulatory Networks in Saccharomyces cerevisiae. Science, 298 (5594). pp. 799-804. ISSN 0036-8075. doi:10.1126/science.1075090.

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We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators.

Item Type:Article
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Ren, Bing0000-0002-2829-1554
Additional Information:© 2002 American Association for the Advancement of Science. 14 June 2002; accepted 16 August 2002. We thank J. Terragni, D. Pokholok, J. Lange, and E. Kanin for experimental support; J. Liang for assistance with the supporting Web site; and R. DeShaies, T. Ideker, and T. Jaakkola for helpful discussions. Supported by fellowships from the National Cancer Institute of Canada (F.R.), the Human Frontier Science Program (J.Z.), the Sloan/U.S. Department of Energy Program for Computational Molecular Biology (D.T.O.), the Program in Mathematics and Molecular Biology at Florida State University and Burroughs Wellcome Fund Interfaces Program (Z.B.-J.), and the Helen Hay Whitney Foundation (B.R.). Supported by grants from NIH and Corning Inc.
Funding AgencyGrant Number
National Cancer Institute of CanadaUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
Florida State UniversityUNSPECIFIED
Burroughs Wellcome FundUNSPECIFIED
Helen Hay Whitney FoundationUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:5594
Record Number:CaltechAUTHORS:20141117-103910943
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Official Citation:Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., . . . Young, R. A. (2002). Transcriptional Regulatory Networks in Saccharomyces cerevisiae. Science, 298(5594), 799-804. doi: 10.1126/science.1075090
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51839
Deposited By: Jason Perez
Deposited On:17 Nov 2014 20:09
Last Modified:10 Nov 2021 19:16

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