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Endocannabinoid Signaling in the Brain

Wilson, Rachel I. and Nicoll, Roger A. (2002) Endocannabinoid Signaling in the Brain. Science, 296 (5568). pp. 678-682. ISSN 0036-8075. doi:10.1126/science.1063545. https://resolver.caltech.edu/CaltechAUTHORS:20141117-141648728

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Abstract

The primary psychoactive ingredient in cannabis, Δ^9-tetrahydrocannabinol (Δ^9-THC), affects the brain mainly by activating a specific receptor (CB1). CB1 is expressed at high levels in many brain regions, and several endogenous brain lipids have been identified as CB1 ligands. In contrast to classical neurotransmitters, endogenous cannabinoids can function as retrograde synaptic messengers: They are released from postsynaptic neurons and travel backward across synapses, activating CB1 on presynaptic axons and suppressing neurotransmitter release. Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1063545 DOIArticle
http://www.sciencemag.org/content/296/5568/678PublisherArticle
Additional Information:© 2002 American Association for the Advancement of Science. We thank H. R. Bourne, H. L. Fields, D. Julius, G. Kunos, K. A. Moore, and M. P. Stryker for comments on the manuscript. We also thank B. E. Alger and B. F. Cravatt for sharing data before publication. R.A.N. is a member of the Keck Center for Integrative Neuroscience and the Silvio Conte Center for Neuroscience Research. He is supported by grants from the National Institutes of Health and the Bristol-Myers Squibb Corporation.
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Bristol-Myers Squibb CorporationUNSPECIFIED
Issue or Number:5568
DOI:10.1126/science.1063545
Record Number:CaltechAUTHORS:20141117-141648728
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141117-141648728
Official Citation:Wilson, R. I., & Nicoll, R. A. (2002). Endocannabinoid Signaling in the Brain. Science, 296(5568), 678-682. doi: 10.1126/science.1063545
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51863
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:18 Nov 2014 18:10
Last Modified:10 Nov 2021 19:16

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