A Caltech Library Service

Endocannabinoid Signaling in the Brain

Wilson, Rachel I. and Nicoll, Roger A. (2002) Endocannabinoid Signaling in the Brain. Science, 296 (5568). pp. 678-682. ISSN 0036-8075. doi:10.1126/science.1063545.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


The primary psychoactive ingredient in cannabis, Δ^9-tetrahydrocannabinol (Δ^9-THC), affects the brain mainly by activating a specific receptor (CB1). CB1 is expressed at high levels in many brain regions, and several endogenous brain lipids have been identified as CB1 ligands. In contrast to classical neurotransmitters, endogenous cannabinoids can function as retrograde synaptic messengers: They are released from postsynaptic neurons and travel backward across synapses, activating CB1 on presynaptic axons and suppressing neurotransmitter release. Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism.

Item Type:Article
Related URLs:
URLURL TypeDescription DOIArticle
Additional Information:© 2002 American Association for the Advancement of Science. We thank H. R. Bourne, H. L. Fields, D. Julius, G. Kunos, K. A. Moore, and M. P. Stryker for comments on the manuscript. We also thank B. E. Alger and B. F. Cravatt for sharing data before publication. R.A.N. is a member of the Keck Center for Integrative Neuroscience and the Silvio Conte Center for Neuroscience Research. He is supported by grants from the National Institutes of Health and the Bristol-Myers Squibb Corporation.
Funding AgencyGrant Number
Bristol-Myers Squibb CorporationUNSPECIFIED
Issue or Number:5568
Record Number:CaltechAUTHORS:20141117-141648728
Persistent URL:
Official Citation:Wilson, R. I., & Nicoll, R. A. (2002). Endocannabinoid Signaling in the Brain. Science, 296(5568), 678-682. doi: 10.1126/science.1063545
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51863
Deposited By: Jason Perez
Deposited On:18 Nov 2014 18:10
Last Modified:10 Nov 2021 19:16

Repository Staff Only: item control page