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Breaching the Barrier

Locher, Kaspar P. and Bass, Randal B. and Rees, Douglas C. (2003) Breaching the Barrier. Science, 301 (5633). pp. 603-604. ISSN 0036-8075. doi:10.1126/science.1088621.

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Transporter proteins are integral membrane proteins that selectively mediate the passage of molecules across the otherwise impermeable barrier imposed by the phospholipid bilayer that surrounds all cells and organelles. The identification of more than 360 families of transporters through biochemical and genomic analyses highlights the importance of transport processes to cells. Among the most fascinating transporters are those that act as molecular pumps, translocating their substrates across membranes against a concentration gradient; this thermodynamically unfavorable process is powered by coupling to a second, energetically favorable process such as ATP hydrolysis or the movement of a second solute down a transmembrane concentration gradient.

Item Type:Article
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URLURL TypeDescription DOIArticle
Rees, Douglas C.0000-0003-4073-1185
Additional Information:© 2003 American Association for the Advancement of Science. D. C. Rees is an Investigator with the Howard Hughes Medical Institute.
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5633
Record Number:CaltechAUTHORS:20141118-095025111
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Official Citation:Locher, K. P., Bass, R. B., & Rees, D. C. (2003). Breaching the Barrier. Science, 301(5633), 603-604. doi: 10.1126/science.1088621
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51889
Deposited On:18 Nov 2014 21:14
Last Modified:10 Nov 2021 19:17

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