Locher, Kaspar P. and Bass, Randal B. and Rees, Douglas C. (2003) Breaching the Barrier. Science, 301 (5633). pp. 603-604. ISSN 0036-8075. doi:10.1126/science.1088621. https://resolver.caltech.edu/CaltechAUTHORS:20141118-095025111
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Abstract
Transporter proteins are integral membrane proteins that selectively mediate the passage of molecules across the otherwise impermeable barrier imposed by the phospholipid bilayer that surrounds all cells and organelles. The identification of more than 360 families of transporters through biochemical and genomic analyses highlights the importance of transport processes to cells. Among the most fascinating transporters are those that act as molecular pumps, translocating their substrates across membranes against a concentration gradient; this thermodynamically unfavorable process is powered by coupling to a second, energetically favorable process such as ATP hydrolysis or the movement of a second solute down a transmembrane concentration gradient.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2003 American Association for the Advancement of Science. D. C. Rees is an Investigator with the Howard Hughes Medical Institute. | |||||||||
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| Issue or Number: | 5633 | |||||||||
| DOI: | 10.1126/science.1088621 | |||||||||
| Record Number: | CaltechAUTHORS:20141118-095025111 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141118-095025111 | |||||||||
| Official Citation: | Locher, K. P., Bass, R. B., & Rees, D. C. (2003). Breaching the Barrier. Science, 301(5633), 603-604. doi: 10.1126/science.1088621 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 51889 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | INVALID USER | |||||||||
| Deposited On: | 18 Nov 2014 21:14 | |||||||||
| Last Modified: | 10 Nov 2021 19:17 |
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