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Microfluidic Large-Scale Integration

Thorsen, Todd and Maerkl, Sebastian J. and Quake, Stephen R. (2002) Microfluidic Large-Scale Integration. Science, 298 (5593). pp. 580-584. ISSN 0036-8075. doi:10.1126/science.1076996.

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We developed high-density microfluidic chips that contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large-scale integration. A key component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. We used these integrated microfluidic networks to construct the microfluidic analog of a comparator array and a microfluidic memory storage device whose behavior resembles random-access memory.

Item Type:Article
Related URLs:
URLURL TypeDescription DOIArticle
Maerkl, Sebastian J.0000-0003-1917-5268
Quake, Stephen R.0000-0002-1613-0809
Additional Information:© 2002 American Association for the Advancement of Science. 5 August 2002; accepted 17 September 2002; published online 26 September 2002. We thank M. Enzelberger, C. Hansen, M. Adams, and M. Unger for helpful discussions. Supported in part by Army Research Office grant DAAD19-00-1-0392 and by the DARPA Bioflips program.
Funding AgencyGrant Number
Army Research Office (ARO)DAAD19-00-1-0392
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Issue or Number:5593
Record Number:CaltechAUTHORS:20141118-095328959
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Official Citation:Thorsen, T., Maerkl, S. J., & Quake, S. R. (2002). Microfluidic Large-Scale Integration. Science, 298(5593), 580-584. doi: 10.1126/science.1076996
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51891
Deposited By: Jason Perez
Deposited On:18 Nov 2014 19:20
Last Modified:10 Nov 2021 19:17

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