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Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF^(TIR1) in Mediating Auxin Response

Schwechheimer, Claus and Serino, Giovanna and Callis, Judy and Crosby, William L. and Lyapina, Svetlana and Deshaies, Raymond J. and Gray, William M. and Estelle, Mark and Deng, Xing-Wang (2001) Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF^(TIR1) in Mediating Auxin Response. Science, 292 (5520). pp. 1379-1382. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141118-111944453

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Abstract

The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling development in Arabidopsis. Here, we show that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCF^(TIR1). Furthermore, we found that the COP9 signalosome and SCF^(TIR1) interacted in vivo and that the COP9 signalosome was required for efficient degradation of PSIAA6, a candidate substrate of SCF^(TIR1). Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase–mediated responses.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.sciencemag.org/content/292/5520/1379.abstractPublisherArticle
http://dx.doi.org/10.1126/science.1059776DOIArticle
http://www.sciencemag.org/content/292/5520/1379/suppl/DC1PublisherSupplementary Data
ORCID:
AuthorORCID
Deshaies, Raymond J.0000-0002-3671-9354
Additional Information:© 2001 American Association for the Advancement of Science. 12 February 2001; accepted 10 April 2001. Published online 3 May 2001; 10.1126/science.1059776. Include this information when citing this paper. We thank the Arabidopsis Biological Resource Center at Ohio State University for expressed sequence tag clones. This work was supported by a NSF grant (MCD-0077217) to X.-W.D. C.S. is a postdoctoral fellow of the Deutsche Forschungsgemeinschaft (Schw751/1-1), G.S. was a fellow of the Istituto Pasteur-Fondazione Cenci-Bolognetti, and X.-W.D. is a NSF Presidential Faculty Fellow.
Funders:
Funding AgencyGrant Number
NSFMCD-0077217
Deutsche Forschungsgemeinschaft (DFG)Schw751/1-1
Istituto Pasteur-Fondazione Cenci-BolognettiUNSPECIFIED
NSFUNSPECIFIED
Issue or Number:5520
Record Number:CaltechAUTHORS:20141118-111944453
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141118-111944453
Official Citation:Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response Claus Schwechheimer, Giovanna Serino, Judy Callis, William L. Crosby, Svetlana Lyapina, Raymond J. Deshaies, William M. Gray, Mark Estelle, and Xing-Wang Deng Science 18 May 2001: 292 (5520), 1379-1382.Published online 3 May 2001 [DOI:10.1126/science.1059776]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51905
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:18 Nov 2014 21:13
Last Modified:03 Oct 2019 07:37

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