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Ectodermal Wnt Function as a Neural Crest Inducer

García-Castro, Martín I. and Marcelle, Christophe and Bronner-Fraser, Marianne (2002) Ectodermal Wnt Function as a Neural Crest Inducer. Science, 297 (5582). pp. 848-851. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141118-131539860

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Abstract

Neural crest cells, which generate peripheral nervous system and facial skeleton, arise at the neural plate/ectodermal border via an inductive interaction between these tissues. Wnts and bone morphogenetic proteins (BMPs) play roles in neural crest induction in amphibians and zebrafish. Here, we show that, in avians, Wnt6 is localized in ectoderm and in vivo inhibition of Wnt signaling perturbs neural crest formation. Furthermore, Wnts induce neural crest from naı̈ve neural plates in vitro in a defined medium without added factors, whereas BMPs require additives. Our data suggest that Wnt molecules are necessary and sufficient to induce neural crest cells in avian embryos.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1070824DOIArticle
http://www.sciencemag.org/content/297/5582/848.longPublisherArticle
http://www.sciencemag.org/content/297/5582/848/suppl/DC1PublisherSupporting Online Material
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2002 American Association for the Advancement of Science. 12 February 2002; accepted 28 May 2002; published online 13 June 2002. Supported by NIH grant number NS36585. We thank C. Baker, A. Groves, and A. Knecht for helpful comments on this work.
Funders:
Funding AgencyGrant Number
NIHNS36585
Issue or Number:5582
Record Number:CaltechAUTHORS:20141118-131539860
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141118-131539860
Official Citation:Garcı́a-Castro, M. n. I., Marcelle, C., & Bronner-Fraser, M. (2002). Ectodermal Wnt Function as a Neural Crest Inducer. Science, 297(5582), 848-851. doi: 10.1126/science.1070824
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51911
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:18 Nov 2014 21:40
Last Modified:03 Oct 2019 07:37

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