Conaway, Ronald C. and Brower, Christopher S. and Conaway, Joan Weliky (2002) Emerging Roles of Ubiquitin in Transcription Regulation. Science, 296 (5571). pp. 1254-1258. ISSN 0036-8075. doi:10.1126/science.1067466. https://resolver.caltech.edu/CaltechAUTHORS:20141118-151303918
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20141118-151303918
Abstract
Ubiquitin is a small protein that was initially found to function as a tag that can be covalently attached to proteins to mark them for destruction by a multisubunit, adenosine 5′-triphosphate–dependent protease called the proteasome. Ubiquitin is now emerging as a key regulator of eukaryotic messenger RNA synthesis, a process that depends on the RNA synthetic enzyme RNA polymerase II and the transcription factors that control its activity. Ubiquitin controls messenger RNA synthesis not only by mechanisms involving ubiquitin-dependent destruction of transcription factors by the proteasome, but also by an intriguing collection of previously unknown and unanticipated mechanisms that appear to be independent of the proteasome.
Item Type: | Article | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| |||||||||
Additional Information: | © 2002 American Association for the Advancement of Science. Work in the author's laboratory is supported by NIH grant R37 6M41628 (to R.C.C.). | |||||||||
Funders: |
| |||||||||
Issue or Number: | 5571 | |||||||||
DOI: | 10.1126/science.1067466 | |||||||||
Record Number: | CaltechAUTHORS:20141118-151303918 | |||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141118-151303918 | |||||||||
Official Citation: | Emerging Roles of Ubiquitin in Transcription Regulation Ronald C. Conaway, Christopher S. Brower, and Joan Weliky Conaway Science 17 May 2002: 296 (5571), 1254-1258. [DOI:10.1126/science.1067466] | |||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
ID Code: | 51925 | |||||||||
Collection: | CaltechAUTHORS | |||||||||
Deposited By: | Ruth Sustaita | |||||||||
Deposited On: | 18 Nov 2014 23:57 | |||||||||
Last Modified: | 10 Nov 2021 19:17 |
Repository Staff Only: item control page