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Emerging Roles of Ubiquitin in Transcription Regulation

Conaway, Ronald C. and Brower, Christopher S. and Conaway, Joan Weliky (2002) Emerging Roles of Ubiquitin in Transcription Regulation. Science, 296 (5571). pp. 1254-1258. ISSN 0036-8075. doi:10.1126/science.1067466.

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Ubiquitin is a small protein that was initially found to function as a tag that can be covalently attached to proteins to mark them for destruction by a multisubunit, adenosine 5′-triphosphate–dependent protease called the proteasome. Ubiquitin is now emerging as a key regulator of eukaryotic messenger RNA synthesis, a process that depends on the RNA synthetic enzyme RNA polymerase II and the transcription factors that control its activity. Ubiquitin controls messenger RNA synthesis not only by mechanisms involving ubiquitin-dependent destruction of transcription factors by the proteasome, but also by an intriguing collection of previously unknown and unanticipated mechanisms that appear to be independent of the proteasome.

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Additional Information:© 2002 American Association for the Advancement of Science. Work in the author's laboratory is supported by NIH grant R37 6M41628 (to R.C.C.).
Funding AgencyGrant Number
NIHR37 6M41628
Issue or Number:5571
Record Number:CaltechAUTHORS:20141118-151303918
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Official Citation:Emerging Roles of Ubiquitin in Transcription Regulation Ronald C. Conaway, Christopher S. Brower, and Joan Weliky Conaway Science 17 May 2002: 296 (5571), 1254-1258. [DOI:10.1126/science.1067466]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51925
Deposited By: Ruth Sustaita
Deposited On:18 Nov 2014 23:57
Last Modified:10 Nov 2021 19:17

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