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Synchrony Dynamics During Initiation, Failure, and Rescue of the Segmentation Clock

Riedel-Kruse, Ingmar H. and Müller, Claudia and Oates, Andrew C. (2007) Synchrony Dynamics During Initiation, Failure, and Rescue of the Segmentation Clock. Science, 317 (5846). pp. 1911-1915. ISSN 0036-8075.

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The “segmentation clock” is thought to coordinate sequential segmentation of the body axis in vertebrate embryos. This clock comprises a multicellular genetic network of synchronized oscillators, coupled by intercellular Delta-Notch signaling. How this synchrony is established and how its loss determines the position of segmentation defects in Delta and Notch mutants are unknown. We analyzed the clock's synchrony dynamics by varying strength and timing of Notch coupling in zebra-fish embryos with techniques for quantitative perturbation of gene function. We developed a physical theory based on coupled phase oscillators explaining the observed onset and rescue of segmentation defects, the clock's robustness against developmental noise, and a critical point beyond which synchrony decays. We conclude that synchrony among these genetic oscillators can be established by simultaneous initiation and self-organization and that the segmentation defect position is determined by the difference between coupling strength and noise.

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Additional Information:© 2007 American Association for the Advancement of Science. Received 14 March 2007; accepted 2 August 2007; Published online 16 August 2007. We thank the MPI-CBG fish facility; S. Ares, L. Morelli, C.-P. Heisenberg, L. Rohde, I.-M. Tolic, E. Paluch, Z. Stardust, and members of the Oates and Laurent lab for ideas and critical comments; Zebrafish International Resource Center for cb1045 plasmid; and J. Howard, G. Laurent, a Della Martin fellowship, the Beckman foundation, and D. Kruse for support of I.H.R.-K. We apologize to authors who were not cited because of space constraints. This work was supported by the Max Planck Society. Author contributions are as follows: I.H.R.-K. and A.C.O., project design, data analysis, and manuscript preparation; all authors, experiments; and I.H.R.-K., theory and fitting.
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Della Martin FellowshipUNSPECIFIED
Arnold and Mabel Beckman FoundationUNSPECIFIED
Max Planck SocietyUNSPECIFIED
Record Number:CaltechAUTHORS:20141119-093013399
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51946
Deposited By: Tony Diaz
Deposited On:19 Nov 2014 23:36
Last Modified:27 Feb 2018 21:57

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