A Caltech Library Service

Kinetics of Morphogen Gradient Formation

Kicheva, Anna and Pantazis, Periklis and Bollenbach, Tobias and Kalaidzidis, Yannis and Bittig, Thomas and Jülicher, Frank and González-Gaitán, Marcos (2007) Kinetics of Morphogen Gradient Formation. Science, 315 (5811). pp. 521-525. ISSN 0036-8075. doi:10.1126/science.1135774.

PDF - Supplemental Material
See Usage Policy.

[img] Video (QuickTime) - Supplemental Material
See Usage Policy.

[img] Video (QuickTime) - Supplemental Material
See Usage Policy.

[img] Video (QuickTime) - Supplemental Material
See Usage Policy.


Use this Persistent URL to link to this item:


In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg) form gradients of concentration providing positional information. Dpp forms a longer-range gradient than Wg. To understand how the range is controlled, we measured the four key kinetic parameters governing morphogen spreading: the production rate, the effective diffusion coefficient, the degradation rate, and the immobile fraction. The four parameters had different values for Dpp versus Wg. In addition, Dynamin-dependent endocytosis was required for spreading of Dpp, but not Wg. Thus, the cellular mechanisms of Dpp and Wingless spreading are different: Dpp spreading requires endocytic, intracellular trafficking.

Item Type:Article
Related URLs:
URLURL TypeDescription DOIArticle Information
Pantazis, Periklis0000-0002-8367-9332
Bollenbach, Tobias0000-0003-4398-476X
Additional Information:© 2007 American Association for the Advancement of Science. 2 October 2006; Accepted 6 December 2006. We thank J.-P. Vincent and A. Charpilienne for reagents, C. P. Heisenberg and E. Entchev for critical reading of the manuscript, as well as all members of the M.G.-G. and F.J. groups. This work was supported by the Max Planck Society, Deutsche Forchungsgemeinschaft, Volkswagen Stiftung, the European Union, and the Human Frontier Science Program.
Funding AgencyGrant Number
Max Planck SocietyUNSPECIFIED
Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
Volkswagen StiftungUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Issue or Number:5811
Record Number:CaltechAUTHORS:20141119-121008388
Persistent URL:
Official Citation:Kicheva, A., Pantazis, P., Bollenbach, T., Kalaidzidis, Y., Bittig, T., Jülicher, F., & González-Gaitán, M. (2007). Kinetics of Morphogen Gradient Formation. Science, 315(5811), 521-525. doi: 10.1126/science.1135774
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51966
Deposited By: Joanne McCole
Deposited On:19 Nov 2014 21:07
Last Modified:10 Nov 2021 19:18

Repository Staff Only: item control page