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Kinetics of Morphogen Gradient Formation

Kicheva, Anna and Pantazis, Periklis and Bollenbach, Tobias and Kalaidzidis, Yannis and Bittig, Thomas and Jülicher, Frank and González-Gaitán, Marcos (2007) Kinetics of Morphogen Gradient Formation. Science, 315 (5811). pp. 521-525. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141119-121008388

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Abstract

In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg) form gradients of concentration providing positional information. Dpp forms a longer-range gradient than Wg. To understand how the range is controlled, we measured the four key kinetic parameters governing morphogen spreading: the production rate, the effective diffusion coefficient, the degradation rate, and the immobile fraction. The four parameters had different values for Dpp versus Wg. In addition, Dynamin-dependent endocytosis was required for spreading of Dpp, but not Wg. Thus, the cellular mechanisms of Dpp and Wingless spreading are different: Dpp spreading requires endocytic, intracellular trafficking.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1135774 DOIArticle
http://www.sciencemag.org/content/315/5811/521PublisherArticle
http://www.sciencemag.org/content/315/5811/521/suppl/DC1PublisherSupporting Information
ORCID:
AuthorORCID
Pantazis, Periklis0000-0002-8367-9332
Bollenbach, Tobias0000-0003-4398-476X
Additional Information:© 2007 American Association for the Advancement of Science. 2 October 2006; Accepted 6 December 2006. We thank J.-P. Vincent and A. Charpilienne for reagents, C. P. Heisenberg and E. Entchev for critical reading of the manuscript, as well as all members of the M.G.-G. and F.J. groups. This work was supported by the Max Planck Society, Deutsche Forchungsgemeinschaft, Volkswagen Stiftung, the European Union, and the Human Frontier Science Program.
Funders:
Funding AgencyGrant Number
Max Planck SocietyUNSPECIFIED
Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
Volkswagen StiftungUNSPECIFIED
European UnionUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Issue or Number:5811
Record Number:CaltechAUTHORS:20141119-121008388
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141119-121008388
Official Citation:Kicheva, A., Pantazis, P., Bollenbach, T., Kalaidzidis, Y., Bittig, T., Jülicher, F., & González-Gaitán, M. (2007). Kinetics of Morphogen Gradient Formation. Science, 315(5811), 521-525. doi: 10.1126/science.1135774
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51966
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:19 Nov 2014 21:07
Last Modified:03 Oct 2019 07:37

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