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A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila

Chen, Chun-Hong and Huang, Haixia and Ward, Catherine M. and Su, Jessica T. and Schaeffer, Lorian V. and Guo, Ming and Hay, Bruce A. (2007) A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila. Science, 316 (5824). pp. 597-600. ISSN 0036-8075. doi:10.1126/science. 1138595. https://resolver.caltech.edu/CaltechAUTHORS:20141119-123949117

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Abstract

One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements in Drosophila that drive population replacement and are resistant to recombination-mediated dissociation of drive and disease refractoriness functions. These selfish elements use microRNA-mediated silencing of a maternally expressed gene essential for embryogenesis, which is coupled with early zygotic expression of a rescuing transgene.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science. 1138595DOIArticle
http://www.sciencemag.org/content/316/5824/597/suppl/DC1PublisherSupporting Information
Additional Information:© 2007 American Association for the Advancement of Science. 8 December 2006; Accepted 20 March 2007; Published online 29 March 2007. This work did not receive specific funding. It was supported by NIH grants GM057422 and GM70956 to B.A.H. and NS042580 and NS048396 to M.G. C.-H.C. was supported by the Moore Foundation Center for Biological Circuit Design. We thank two reviewers for useful comments and improvements on the manuscript. GenBank accession numbers for Medea^(myd88) and Medea^(myd88-int) are EF447106 and EF447105, respectively.
Funders:
Funding AgencyGrant Number
NIHGM057422
NIHGM70956
NIHNS042580
NIHNS048396
Gordon and Betty Moore FoundationUNSPECIFIED
Issue or Number:5824
DOI:10.1126/science. 1138595
Record Number:CaltechAUTHORS:20141119-123949117
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141119-123949117
Official Citation:Chen, C.-H., Huang, H., Ward, C. M., Su, J. T., Schaeffer, L. V., Guo, M., & Hay, B. A. (2007). A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila. Science, 316(5824), 597-600. doi: 10.1126/science. 1138595
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51968
Collection:CaltechAUTHORS
Deposited By:INVALID USER
Deposited On:19 Nov 2014 22:49
Last Modified:10 Nov 2021 19:18

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